Ch 25 - Skin Flashcards
Acute or chronic inflammatory dermatoses:
Urticaria
Acute eczematous dermatitis
Erythema multiforme
Acute inflammatory dermatoses
Characteristic morphology of dermatofibrosarcoma protuberans
Storiform pattern - closely packed fibroblasts arranged radially (pinwheel appearance)
Per Dr. Martin - fish swimming together appearance
6 P’s of lichen planus
Pruritic Purple Polygonal Planar Papules Plaques (coalescence of papules)
What type of hypersensitivity is acute eczematous dermatitis?
Type IV
Saw-toothing (dermal-epidermal junction takes on zig-zag contour), colloid/Civatte bodies (necrotic basal cells sloughed off and incorporated into inflamed papillary dermis), and acanthosis in chronic form are seen in _______
Lichen planus
Tumor of the dermis with the following:
Translocation: COL1A1 and PDGFβ (platelet derived growth factor beta)
Overexpression of PDGFβ -> tumor cell growth through an autocrine loop
Dermatofibrosarcoma protuberans
Stain used with fungi (stain bright pink/red)
PAS
Most common form of fibrous histiocytoma
Dermatofibroma (benign fibrous histiocytoma)
Acute inflammatory dermatosis characterized by spongiosis (edema seeps into intercellular spaces of epidermis, splaying apart keratinocytes (acantholysis), particularly in stratum spinosum)
Acute eczematous dermatitis
Stratum corneum keratinization with retained nuclei
Normal on mucous membranes
Parakeratosis
Malignant tumor of the dermis that rarely metastasizes (but still malignant)
Dermatofibrosarcoma protuberans
Panniculitis associated with infectious β-hemolytic strep, tuberculosis, sarcoidosis, and IBD
Leaves no scars while new lesions develop
Erythema nodosum
Infection usually due to staph aureus and has a honey-colored crust morphology
Impetigo
Pemphigus or bullous pemphigoid - subepidermal, non-acantholytic blisters
Bullous pemphigoid
Parakeratosis (thickened stratum corneum that retain their nuclei unlike normal cells in this layer) is seen in ______
Actinic (solar) keratoses
Chronic inflammatory dermatosis that presents with wickham striae (white dots or lines that highlight papules) and white, lace-like oral lesions
Lichen planus
Most common form of panniculitis (inflammation of subcutaneous adipose tissue affecting lobules of fat and/or connective tissues that separates fat into lobules)
Erythema nodosum
Pemphigus (inflammatory blistering disorder due to autoantibodies that lead to dissolution of intercellular attachments within epidermis and mucosal epithelium) has the following pathogenesis:
_____ autoantibodies against desmogleins ___ and ___
IgG autoantibodies
Desmogleins 1 and 3
Pemphigus or bullous pemphigoid - epidermal, acantholytic blisters
Pemphigus
Most common pigmented lesions of childhood in lightly pigmented individuals
Ephelis (freckle)
Most common invasive cancer in humans
Most common malignancy worldwide
Associated with mutations that activate hedgehog signaling pathway
Basal cell carcinoma (BCC)
Tumor of cellular migrant to the skin with prognosis based on percent of body surface involved and progression of patch -> plaque -> nodule
Mycosis fungoides (cutaneous T-cell lymphoma)
Tumor of cellular migrant to the skin with the following presentation: systemic disease with pruritis, flushing, watery nasal discharge, bone pain (osteoporosis due to increased histamine in marrow, especially in premenopausal women and men)
Mastocytosis
Acute or chronic inflammatory dermatoses:
Psoriasis
Seborrheic dermatitis
Lichen planus
Chronic inflammatory dermatoses
4th stage of rosacea characterized by permanent thickening of nasal skin via confluent erythematous papules and prime time follicles, associated with hypertrophy of sebaceous glands and follicular plugging by keratitis debris
Rhinophyma
Syndrome characterized by trichellomomas (benign cutaneous neoplasm) and breast/endometrial/other cancers
Cowden syndrome
