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MSK II Robbins Notes > Ch 25 - Skin > Flashcards

Ch 25 - Skin Flashcards

1
Q

Acute or chronic inflammatory dermatoses:
Urticaria
Acute eczematous dermatitis
Erythema multiforme

A

Acute inflammatory dermatoses

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2
Q

Characteristic morphology of dermatofibrosarcoma protuberans

A

Storiform pattern - closely packed fibroblasts arranged radially (pinwheel appearance)
Per Dr. Martin - fish swimming together appearance

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3
Q

6 P’s of lichen planus

A 
Pruritic
Purple
Polygonal
Planar
Papules
Plaques (coalescence of papules)
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4
Q

What type of hypersensitivity is acute eczematous dermatitis?

A

Type IV

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5
Q

Saw-toothing (dermal-epidermal junction takes on zig-zag contour), colloid/Civatte bodies (necrotic basal cells sloughed off and incorporated into inflamed papillary dermis), and acanthosis in chronic form are seen in _______

A

Lichen planus

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6
Q

Tumor of the dermis with the following:
Translocation: COL1A1 and PDGFβ (platelet derived growth factor beta)
Overexpression of PDGFβ -> tumor cell growth through an autocrine loop

A

Dermatofibrosarcoma protuberans

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7
Q

Stain used with fungi (stain bright pink/red)

A

PAS

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8
Q

Most common form of fibrous histiocytoma

A

Dermatofibroma (benign fibrous histiocytoma)

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9
Q

Acute inflammatory dermatosis characterized by spongiosis (edema seeps into intercellular spaces of epidermis, splaying apart keratinocytes (acantholysis), particularly in stratum spinosum)

A

Acute eczematous dermatitis

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10
Q

Stratum corneum keratinization with retained nuclei

Normal on mucous membranes

A

Parakeratosis

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11
Q

Malignant tumor of the dermis that rarely metastasizes (but still malignant)

A

Dermatofibrosarcoma protuberans

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12
Q

Panniculitis associated with infectious β-hemolytic strep, tuberculosis, sarcoidosis, and IBD
Leaves no scars while new lesions develop

A

Erythema nodosum

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13
Q

Infection usually due to staph aureus and has a honey-colored crust morphology

A

Impetigo

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14
Q

Pemphigus or bullous pemphigoid - subepidermal, non-acantholytic blisters

A

Bullous pemphigoid

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15
Q

Parakeratosis (thickened stratum corneum that retain their nuclei unlike normal cells in this layer) is seen in ______

A

Actinic (solar) keratoses

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16
Q

Chronic inflammatory dermatosis that presents with wickham striae (white dots or lines that highlight papules) and white, lace-like oral lesions

A

Lichen planus

17
Q

Most common form of panniculitis (inflammation of subcutaneous adipose tissue affecting lobules of fat and/or connective tissues that separates fat into lobules)

A

Erythema nodosum

18
Q

Pemphigus (inflammatory blistering disorder due to autoantibodies that lead to dissolution of intercellular attachments within epidermis and mucosal epithelium) has the following pathogenesis:
_____ autoantibodies against desmogleins ___ and ___

A

IgG autoantibodies

Desmogleins 1 and 3

19
Q

Pemphigus or bullous pemphigoid - epidermal, acantholytic blisters

A

Pemphigus

20
Q

Most common pigmented lesions of childhood in lightly pigmented individuals

A

Ephelis (freckle)

21
Q

Most common invasive cancer in humans
Most common malignancy worldwide
Associated with mutations that activate hedgehog signaling pathway

A

Basal cell carcinoma (BCC)

22
Q

Tumor of cellular migrant to the skin with prognosis based on percent of body surface involved and progression of patch -> plaque -> nodule

A

Mycosis fungoides (cutaneous T-cell lymphoma)

23
Q

Tumor of cellular migrant to the skin with the following presentation: systemic disease with pruritis, flushing, watery nasal discharge, bone pain (osteoporosis due to increased histamine in marrow, especially in premenopausal women and men)

A

Mastocytosis

24
Q

Acute or chronic inflammatory dermatoses:
Psoriasis
Seborrheic dermatitis
Lichen planus

A

Chronic inflammatory dermatoses

25
Q

4th stage of rosacea characterized by permanent thickening of nasal skin via confluent erythematous papules and prime time follicles, associated with hypertrophy of sebaceous glands and follicular plugging by keratitis debris

A

Rhinophyma

26
Q

Syndrome characterized by trichellomomas (benign cutaneous neoplasm) and breast/endometrial/other cancers

A

Cowden syndrome

MSK II Robbins Notes (3 decks)

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