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path 2 test 3 > ch 23 > Flashcards

ch 23 Flashcards

0
Q

Spongiosis

A

intracellular epidermal edema

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1
Q

Acantholysis

A

loss of intercellular keratinocyteadhesion

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2
Q

what is urticaria

A

Hives
this is a type I hypersensitivity
20-40 year olds
fades in 24 hours

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3
Q

what is hereditary angioedema urticaria

A

this is a inherited disease of C1 esterase inhibitor deficiency
could be deadly if it involves the pharynx

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4
Q

what is eczema (allergic contact dermatitis)

A

this is a type IV hypersensitivity reaction (delayed)
limited to site of contact
itchy edematous, oozing

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5
Q

atopic dermatitis

A

subcategory of eczema

childhood onset, improves with age

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6
Q

what is the atopic triad

A

asthma
allergic rhinitis
Atopic dermatitis

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7
Q

erythema multiforme

A

type IV hypersensitivity
“Targetoid lesions”
lesions is erosive and hemorrhagic crusts
septic infection

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8
Q

what are the 2 types of erythema multiforme

A

erythema multiforme minor (post-infection) more mild

erythema multiforme major (drug reaction ) severe epidermal damage

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9
Q

what is Psoriasis

A

“Well-demarcated, pink to salmon-colored plaquecovered by loosely adherent silver-white scale”

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10
Q

what is the Koebner phenomenon

A

Psoriasis that is caused by Local trauma: unregulated inflammation

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11
Q

what are the Lichen planus 6P’s

A

pruritic, purple, polygonal, planar, papules, plaques

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12
Q

what part of the skin does Lichen planus form and how long does it last

A

dermoepidermal

1-2 years

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13
Q

what is lichen simplex chronicus

A

rough skin that is idiopathic caused by chronic repetitive trauma that will leave dermal scaring
may accompany eczema or psoriasis

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14
Q

what is impetigo

A

superficial bacterial infection from staph. aureus with a honey-colored crusts

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15
Q

what is another name for a fungal infection of the skin

A

mycosis

16
Q

what is mycosis

A

Dermatophytosis (ringworm)
more aggressive (Aspergillus fumigatus), angioinvasive
possible granuloma formation (coming together of macrophages)

17
Q

what is another name for Verrucae

A

wart

18
Q

what is a Verrucae

A 
verruca vulgaris MC type of wart 
verruca plana (flat wart)
19
Q

what will cause Verrucae to become large 2 cm

A

immunodeficiency

20
Q

what is a Bullous disorders

A

blister

21
Q

what is most common type of Bullous disorders

A

secondary to other conditions

22
Q

what is pemphigus

A

a rare autoimmune blistering disorder
type II hypersensitivity
IgG with a fishnet like pattern

23
Q

Pemphigus vulgaris

A

MC Pemphigus
suprabasal
Mucous membranes & skin

24
Q

Pemphigus foliaceus

A

subcorneal

rare limited to the skin

25
Q

Bullous pemphigoid

A 
Type II hypersensitivity
 Subepidermal blister (below the skin)
 “Tense bullae” - serous filled
older adults 
IgG (linear)
26
Q

Dermatitis herpetiformis

A

Associated with celiac disease
dorsal elbow
IgA antibodies: dermal papillae

27
Q

what are the 3 Benign epithelial lesions

A
  1. Seborrheic keratosis
  2. Sebaceous adenoma
  3. Actinic keratosis
28
Q

what is Seborrheic keratosis

A

Benign epidermal tumors
Flat, round, “coin-like” “stuck-on” plaques
brown
numerous (100s)

29
Q

Sebaceous adenoma

A

benign skin condition
Flesh-colored papule
slow-growing
head and neck

30
Q

what is actinic keratosis

A 
Dysplastic changes precede epidermal CA
MC with light skin pigment
tan-brown, red, or skin-toned 
“sandpaper-like”
<1 cm
31
Q

Solar lentigo

A

AKA: liver spots
Hyperplasia of melanocytes
Prolonged UV exposure
May disguise CA

32
Q

Squamous cell carcinoma (SCC

A

Common form of CA
↑ total sun exposure
tar & oil, burns
arsenic-containing compounds

33
Q

what do SCC arise from and what do they look like

A

Arise from prior actinic keratoses

Sharply-defined lesions, dark brown or red color

34
Q

what is the most common form of skin cancer

A

Basal cell carcinoma

35
Q

what pathway is involved in Basal cell carcinoma

A

Hedgehog pathway

36
Q

what does basal cell carcinoma look like

A

Cells resemble normal basal cells
“Pearly papules,”
Advanced: ulceration, bone & sinus invasion

path 2 test 3 (2 decks)

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