ch 23

Question 0

Spongiosis

Answer 0

intracellular epidermal edema

Question 1

Acantholysis

Answer 1

loss of intercellular keratinocyteadhesion

Question 2

what is urticaria

Answer 2

Hives
this is a type I hypersensitivity
20-40 year olds
fades in 24 hours

Question 3

what is hereditary angioedema urticaria

Answer 3

this is a inherited disease of C1 esterase inhibitor deficiency
could be deadly if it involves the pharynx

Question 4

what is eczema (allergic contact dermatitis)

Answer 4

this is a type IV hypersensitivity reaction (delayed)
limited to site of contact
itchy edematous, oozing

Question 5

atopic dermatitis

Answer 5

subcategory of eczema

childhood onset, improves with age

Question 6

what is the atopic triad

Answer 6

asthma
allergic rhinitis
Atopic dermatitis

Question 7

erythema multiforme

Answer 7

type IV hypersensitivity
“Targetoid lesions”
lesions is erosive and hemorrhagic crusts
septic infection

Question 8

what are the 2 types of erythema multiforme

Answer 8

erythema multiforme minor (post-infection) more mild

erythema multiforme major (drug reaction ) severe epidermal damage

Question 9

what is Psoriasis

Answer 9

“Well-demarcated, pink to salmon-colored plaquecovered by loosely adherent silver-white scale”

Question 10

what is the Koebner phenomenon

Answer 10

Psoriasis that is caused by Local trauma: unregulated inflammation

Question 11

what are the Lichen planus 6P’s

Answer 11

pruritic, purple, polygonal, planar, papules, plaques

Question 12

what part of the skin does Lichen planus form and how long does it last

Answer 12

dermoepidermal

1-2 years

Question 13

what is lichen simplex chronicus

Answer 13

rough skin that is idiopathic caused by chronic repetitive trauma that will leave dermal scaring
may accompany eczema or psoriasis

Question 14

what is impetigo

Answer 14

superficial bacterial infection from staph. aureus with a honey-colored crusts

Question 15

what is another name for a fungal infection of the skin

Answer 15

mycosis

Question 16

what is mycosis

Answer 16

Dermatophytosis (ringworm)
more aggressive (Aspergillus fumigatus), angioinvasive
possible granuloma formation (coming together of macrophages)

Question 17

what is another name for Verrucae

Answer 17

wart

Question 18

what is a Verrucae

Answer 18

verruca vulgaris MC type of wart 
verruca plana (flat wart)

Question 19

what will cause Verrucae to become large 2 cm

Answer 19

immunodeficiency

Question 20

what is a Bullous disorders

Answer 20

blister

Question 21

what is most common type of Bullous disorders

Answer 21

secondary to other conditions

Question 22

what is pemphigus

Answer 22

a rare autoimmune blistering disorder
type II hypersensitivity
IgG with a fishnet like pattern

Question 23

Pemphigus vulgaris

Answer 23

MC Pemphigus
suprabasal
Mucous membranes & skin

Question 24

Pemphigus foliaceus

Answer 24

subcorneal | rare limited to the skin

Question 25

Bullous pemphigoid

Answer 25

``` Type II hypersensitivity Subepidermal blister (below the skin) “Tense bullae” - serous filled older adults IgG (linear) ```

Question 26

Dermatitis herpetiformis

Answer 26

Associated with celiac disease dorsal elbow IgA antibodies: dermal papillae

Question 27

what are the 3 Benign epithelial lesions

Answer 27

1. Seborrheic keratosis 2. Sebaceous adenoma 3. Actinic keratosis

Question 28

what is Seborrheic keratosis

Answer 28

Benign epidermal tumors Flat, round, “coin-like” “stuck-on” plaques brown numerous (100s)

Question 29

Sebaceous adenoma

Answer 29

benign skin condition Flesh-colored papule slow-growing head and neck

Question 30

what is actinic keratosis

Answer 30

``` Dysplastic changes precede epidermal CA MC with light skin pigment tan-brown, red, or skin-toned “sandpaper-like” <1 cm ```

Question 31

Solar lentigo

Answer 31

AKA: liver spots Hyperplasia of melanocytes Prolonged UV exposure May disguise CA

Question 32

Squamous cell carcinoma (SCC

Answer 32

Common form of CA ↑ total sun exposure tar & oil, burns arsenic-containing compounds

Question 33

what do SCC arise from and what do they look like

Answer 33

Arise from prior actinic keratoses | Sharply-defined lesions, dark brown or red color

Question 34

what is the most common form of skin cancer

Answer 34

Basal cell carcinoma

Question 35

what pathway is involved in Basal cell carcinoma

Answer 35

Hedgehog pathway

Question 36

what does basal cell carcinoma look like

Answer 36

Cells resemble normal basal cells “Pearly papules,” Advanced: ulceration, bone & sinus invasion