Ch 2: Innate immunity

Question 1

Secretory phospholipase A

Answer 1

Can enter through bacterial cell wall and hydrolyze lipids in cell membrane. Secreted by phagocytes, tears, small intestine (Paneth cells)

Question 2

Lectins

Answer 2

Recognize bacterial carbohydrates and forms pores in membrane
 Ex RegIII targets gram positive bacteria

Question 3

Defensins

Answer 3

Cationic peptide, integrates into lipid bilayer to form a pore

Question 4

Cathelicidins

Answer 4

Disrupts pathogen membrane. Found in neutrophil granules and macrophages, require local calcium for propeptide protease

Question 5

Histatins

Answer 5

Against pathogenic fungi. Secreted into oral cavity in saliva