Ch 2 Health and Safety Flashcards
Dose equals _____ x _____
Concentration x time
Toxicologist list 4 categories of factors that influence toxicity
Concentration or dose
Rate of absorption
Rate of detoxification
Rate of excretion
Two units of measurement commonly sided for determining the relative toxicity of a chemical substance or compound
Lethal dose, 50% kill
Lethal concentration 50% kill
The concentration and ingested, absorbed or injected substance, which result in the death of 50% of the test population. This is an oral or dermal exposure expressed in terms of weight – MG/KG.
Lethal dose, 50% kill (LD50)
The concentration of an inhaled substance that results in the death of 50% of the test population in a specific time.
Lethal concentration, 50% kill (LC50)
Maxim, everyone concentration of a material of which an average healthy person may be exposed repeatedly for eight hours each day 40 hours per week without suffering adverse effects ACGIH
TLV/TWA
Maximum time weighted concentration at which 95% of expose healthy adults suffer no adverse effects over a 40 hour work week (2 different)
Permissible exposure limit - OSHA - 8 hour concentration
Recommended exposure levels - Niosh - 10 hour concentration
15 minute time weighted average exposure not repeated more than four times daily with a 60 minute rest.
Short term exposure limit
The maximum concentration that should not be exceeded even instantaneously
TLV/C threshold limit value ceiling
(ACGIH recommends 5 times TLV/TWA used in place of TLV/C)
Three general IDLH atmospheres
Toxic
Flammable
Oxygen deficient
Consider 10 times TLV/TWA as IDLH
This is defined as the maximum air concentration below, which it is believed that nearly all individuals could be exposed for up to 1 hour, without experiencing or developing reversible, or other serious health effects or symptoms
ERPG – 2
How many tiers are there within the Emergency Response Planning Guidelines ERPG? (AIHA)
3
How many tiers and periods are within the Acute Emergency Exposure Guidelines AEGL? (EPA)
3 tiers
5 periods
10 min, 30 min, 1 hr, 4 hr, 8 hr
Four types of ionizing radiation
Alpha, beta, gamma neutron
Characterized by its lack of energy to remove electrons from atoms
Non-ionizing radiation