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GI 2 Exam 2 > Ch 18 Cancer Genes > Flashcards

Ch 18 Cancer Genes Flashcards

1
Q

ANA, ASMA, anti-LKM1, ACL-1

A

autoimmune hepatitis

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2
Q

ALDH1

A

alcoholic hepatitis

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3
Q

HFE (adult)

HAM, HJV (juvenile)

A

hemochromatosis

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4
Q

ATP7B

A

Wilson disease

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5
Q

a1AT

A

alpha1-AT def

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6
Q

HLA-B8 association, T cells in periductal stroma

A

PSC

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7
Q

polycistin gene (occurs with AR polycystic kidney dz)

A

fibropolycystic disease

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8
Q 
HNF1 inactivation (germline mutaiton of MODY-3)
b-catenin activation
gp130 activation (IL6, JAK-STAT)
A

hepatocellular adenomas (benign)

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9
Q

APC, activation of WNT

A

hepatoblastoma

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10
Q

activation of b-catenin

inactivation of TP53 (aflatoxin)

A

hepatocellular carcinoma (malignant)

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11
Q

ABCG8

A

cholelithiasis

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12
Q

ERBB2 overexpression
PBRM1 mutation
MLL3 mutation

A

gallbladder carcinoma

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GI 2 Exam 2 (6 decks)

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