Ch 17 Quantitative Genetics Flashcards
quantitative genetics
genetic analysis of complex characteristics such as the oil content of corn
continuous characteristics
characteristics vary continuously along a scale of measurement
also called quantitative characteristics because any individuals phenotype must be described by a quantitative measurement
two phenomena for quantitative characteristics
1) many are polygenic: influenced by genes at many loci
2) often arise when environmental factors affect the phenotype because environmental differences result in a single genotype producing a range of phenotypes
multifactorial
most continuously varying characteristics are both polygenic and influenced by environmental factors
threshold characteristic
a type of quantitative characteristic that is present or absent
they exhibit only two phenotypes; are determined by multiple genetic and environmental factors
frequency distributions
a graph of the frequencies (numbers or proportions) of the different phenotypes
normal distribution
many quantitative characteristics exhibit a symmetrical (bell-shaped) curve
arise when a large number of independent factors contribute to a measurement
types of distribution
normal, skewed and bimodal
mean
also called the average, is a statistic that provides information about the center of a distribution
variance
indicates the variability of a group of measurements, or how spread out the distribution is
the larger the variance, the greater the spread of measurements in a distribution around its mean
heritability
proportion of the total phenotypic variation that is due to genetic differences
if increased, then largely genetic
if decreased, then largely enviromental
phenotypic variation
represented Vp
we could collect a representative sample of plants from the population, weigh each plant in the sample, and calculate the mean and variance of plant weight
genetic variance
represented Vg
differences in genotypes among individual members of the population
environmental variance
represented Ve
differences in phenotype may be due to environmental differences among the plants
includes differences in environmental factors such as the amount of light or water that the plant receives; it also includes random differences in development that cannot be attributed to any specific factor
genetic-environmental interaction variance
represented Vge
arises when the effect of a gene depends on the specific environment in which it is found
additive genetic variance
represented Va
comprises the additive effects of genes on the phenotype, which can be summed to determine the overall effect on the phenotype
primarily determines the resemblance between parents and offspring
dominance genetic variance
represented Vd
the effects of some genes have a dominance component
the effect of an allele depends on the identity of the other allele at that locus
gene interaction variance
represented Vi
genes at different loci may interact in the same way that alleles at the same locus interact
broad-sense heritability
represented H^2
represents the proportion of phenotypic variance that is due to genetic variance
H^2 = 1 then all your phenotypic variance is due to genetic variance
H^2 = 0 then little phenotypic variance, it is due to environment
narrow-sense heritability
represented h^2
equal to the additive genetic variance divided by the phenotypic variance
limitations of heritability
- Does not indicate the degree to which a characteristic is genetically determined
- an individual does not have heritability
- no universal heritability for a characteristic
- even when heritability is high, environmental factors can influence a characteristic
- heritabilities indicate nothing about the nature of population differences in a characteristic
quantitative trait loci (QTLs)
chromosome regions with genes that control polygenic characteristics
a map location for a chromosome region that is associated with a quantitative trait
natural selection
arises through the differential reproduction of individuals with different genotypes
artificial selection
humans have practiced a form of selection by promoting the reproduction of organisms with traits perceived as desirable
response to selection
the extent to which a characteristic subjected to selection changes in one generation
represented by R and is the difference between the original population and offspring
R= offspring - original population
selection differential
the response to selection thus depends on the degree to which the selected parents differ from the rest of the population
defined as the difference between the mean phenotype of the selected parents and the mean phenotype of the original population
S= breeding parents - original population
realized heritability
heritability determined by a response-to-selection experiment
if certain assumptions are met, this is identical to narrow-sense heritability
standard deviation
expressing deviation from mean in same scale of measurement mean