Ch. 1 (Robbins and Cotran)

Question 1

What are the 3 major classes of cytoskeletal proteins

Answer 1

Actin microfilaments
Intermediate filaments
Microtublules

Question 2

DNA methylation typically results in transcriptional ________

Answer 2

silencing

Question 3

Histone acetylation leads to…

Euchromatin or heterochromatin?

Answer 3

Euchromatin

Question 4

Peroxisomes breakdown ________

Answer 4

fatty acids, generate H2O2

Question 5

What are the two most common forms of DNA variation?

Answer 5

Single nucleotide polymorphisms and copy number variations

Question 6

When flipped to the outer membrane Phosphatidylserine acts as a signal for _________

Answer 6

Apoptosis

Question 7

Kinesins are involved in _______ transport, while Dyneins are involved in _______ transport

Answer 7

Anterograde

Retrograde

Question 8

Vimentin is an intermediate filament of ________ cells

Answer 8

mesenchymal

Question 9

Desmin is an intermediate filament of _________ cells

Answer 9

muscle

Question 10

In hemidesmosomes _______ link intracellular components to the ECM

Answer 10

integrins

Question 11

Autoantibodies most commonly target which type of cadherin protein in pemphigus?

Answer 11

Desmogleins

Question 12

What type of cadherin proteins form belt desmosomes and are associated with actin microfilaments

Answer 12

E-cadherins

Question 13

When cytochrome c leaks into the cytosol it forms complexes with other proteins ultimately activating caspases which induce _______

Answer 13

apoptosis

Question 14

Vascular endothelial growth factor comes from _____ cells

Answer 14

mesenchymal

Question 15

Which growth factor stimulates the formation of granulation tissue?

Answer 15

Epidermal growth factor

Question 16

Kertainocyte growth factor (KGF) is produced by _______

Answer 16

fibroblasts