Ch. 1- A Case For Evolutionary Thinking

Question 0

Pathogens can evolve resistance to drugs

Answer 0

AZT- first anti-retroviral drug had an N3 instead of the regular OH that the nucleotides had and so the virus developed resistance

Question 1

HIV as case study

Answer 1

Illustrates several evolutionary phenomena

Question 2

Host can evolve to resist disease

Answer 2

CCR5 allele resist characteristic for HIV… Common in Europe due to Black Plague and small pox wiping out those without the CCR5 mutant allele

Question 3

Tracking DNA change in HIV

Answer 3

HIV mutates so fast you can track its evolution within a host and from person to person

Ex: doctor infection girlfriend with HIV blood from patient

Question 4

Evolution of virulence

Answer 4

Transmission rate positively correlates with virulence therefore, optimal level of virulence depends on opportunities for transmission

Question 5

Evolution is short-sighted

Answer 5

No goal, no good of the species

Question 6

DNA based phylogenetic tree allows us to…

Answer 6

• reconstruct the origin of traits

- estimate divergence times