Cervical Screening

Question 1

Frequency of smears and age of women

Answer 1

5 yearly HPV test with partial HPV genotype gets and reflex LBC
Women age 25-74

Question 2

Two most common high risk HPV and what percentage of cancers are related to this type

Answer 2

16 & 18

70% squamous cell cancers

Question 3

Viral composition of Gardasil-9

Answer 3

Non-infectious recombinant vaccine prepared from the purified virus-like particles of the major capsid (L1) protein of HPV types 6,11,16,,18, 31,33,45,52,58

Question 4

5 features to be recognized during colposcopy

Answer 4

Surface contour
Blood vessel pattern
Ace to white
Topography
Iodine uptake

Question 5

Transformation zone

Answer 5

Area lying between the original squamous-columnar junction and the new squamous-columnar junction
Squamous-columnar junction undergoes a maturation process/metaplasia and migrates towards the os at the endcevical canal
Oestrogen increases cervical volume and results in reversion of the columnar epithelium onto the ectocervix
Acidic vaginal environment results in meta plasia and a new junction

Question 6

Iodine uptake

Answer 6

Dependent on amount of glycogen in cell which is a reflection of the degree of differentiation

Question 7

Features of a good screening test

Answer 7

The test needs to be effective
Prevent a sig number of deaths
Cost effective
Acceptable to patient
Sensitive and specific