Cervical Cancer

Question 1

What is the main cause of cervical cancer?

Answer 1

• High-risk HPV (hr HPV), STI
  (from persistent HPV infection)

Notes:
- Women AND men can be infected with HPV
- Exposure is ubiquitous
- HPV clears for most women in 8 - 24 months, especially ≤ 24 years old

Question 2

What are the common s/s of cervical cancer?

Answer 2

Usually asymptomatic!!!

Question 3

What are the most common subtypes of cervical cancer?

Answer 3

Subtypes 16 and 18

Question 4

What are the 2020 HPV Vaccine 9v Gardasil recommendations?

Answer 4

• 9 - 14 years/virgin: 2 doses at 0, 6 months
  (more effective if given prior to coitarche)
• 9 - 14 years/sexually active: 3 doses
• 15 - 26 years: 3 doses at 0, 1 - 2, 6 months
• If 1 dose < 15 years: 2 more doses
• 9 - 26 yers and immunocompromised: 3 doses
• 27 - 45 years: Not routine but may be beneficial

Question 5

What are the 2020 cervical cancer screening guidelines?

Answer 5

• 25 - 65 years old:
  - hrHPV every 5 years
  - if +, reflex Pap