Cerebrovascular Disease Flashcards
Cerebrovascular Disease
Brain disorders involving the blood vessels
Stroke
All cerebrovascular disease when symptoms begins <24hrs
- Ischemic vs Hemorrhagic
Ischemic stroke
- Embolic or Thrombotic
- Global or focal hypoxia
- MRI within hours but CT -ve before 24 hours
Hemorrhagic Stroke
- Vascular rupture
- Intracranial or subarachnoid
- MRI & CT immediately after onset
Global Cerebral Ischemia/ Hypoxia
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Watershed Border zone
Ares of the brain or spinal cord that is most distal to the arterial blood supply
1.
2.
3.
Area of Watershed zone most vulnerable to infarcts
Between the ACA & MCA
Types of Ischemic strokes
- Embolic infarctions
2. Thrombotic infarctions
Embolic Infarction (source & predisposing factors)
Source: Cardiac mural thrombus or carotid atheromatous plaque
- Predisposing factors- A-fib, Valvular disease, Myocardial dysfunction
Thrombotic occlusion/infarction
Source- thrombus superimposed on atherosclerotic plaque –> Fragment or embolize
- May lead to lacunar infarcts
- Anterograde extension
Lacunar infarcts
Gross morphology of infarcts
- swollen brain w. wide gyri & narrow sulci
- poor demarcation between white & gray matter
- tissue liquification & cavity filling w/ fluid
Microscopic changes of infarcts up to 24 hours (acute)
Micro-vacuolation –> Cytoplasmic eosinophilia –> Nuclear pyknosis (red nucleus) & karyorrhexis
Microscopic changes of infarcts 24 hours to 2 weeks (subacute)
- Tissue necrosis
- Macrophage influx
- Vascular proliferation
- Reactive gliosis (astrocytes)
Microscopic changes of infarcts after 2 weeks (repair)
Gliosis w/ removal of necrotic tissue