Cerebral Salt Wasting Syndrome

Question 1

In CSWS, what is happening to Na in the kidney?

Answer 1

It is not being reabsorbed by the proximal tubule.

Question 2

What is the purported etiology of CSWS?

Answer 2

Decreased secretion of renin and aldosterone due to decreased sympathetic tone and/or suppressed secretion by natriuretic peptides.

Question 3

Uric acid is _________ in SIADH and _________ in CSWS (high/low?)

Answer 3

Low, also low

Question 4

2 complications of SAH include:

The risk of these is increased with __________ because it causes __________.

Answer 4

Vasospasm and cerebral infarction.

Hyponatremia

Cerebral edema

Question 5

The treatment for hyponatremia - both CSWS and SIADH - associated with intracerebral pathology is:

Answer 5

Hypertonic saline (aka, salt!) 😎

Question 6

A valid diagnosis of CSWS requires these 2 things:

Answer 6

1. Evidence of inappropriate urinary salt losses

2. Reduced “effective arterial blood volume”