Cerebral Physiology

Question 1

Metabolic rate of braine

Answer 1

12_15% of cardiac output

Question 2

Cerebral blood flow (CBF)

Answer 2

50 ml/100 g/min
80% gray matter / 20% white matter

Question 3

How much of the brain energy consaption supports electrophysiologic function ?

Answer 3

60%

Question 4

Neurovascular coupling of brain

Answer 4

Increase cerebral activity (metabolism) ⇒ Increase CBF

Question 5

CBF autoregulated over MAP range

Answer 5

65-150 mmHg

Question 6

Chemical regulation of CBF

Answer 6

1) PaCO2 25-70 mmHg - CPF in normal range
2) If PaO2 less then 60 mmHg ⇒CBF increase dramatically
3) Reduction of body temperature ⇒suppression of cerebral metabolism

Question 7

Systemic vasodilatators and, CBF

Answer 7

Nstronglyarein, nitroprusside, hydroxyzine and Ca channel blockers ⇒vasodilate the cerebral circulation (depending on the MAP )

Question 8

Wave frequency of AWAKE

Answer 8

1) beta-activity
2)16-30Hz

Question 9

Stage-1 NREM sleep /

Answer 9

1) Alfa
2) 7,5-11Hz

Question 10

stage-2 NREM sleep

Answer 10

) theta wave
2) 4.5.7.5 Hz
3) sleep spindle and K-complex

Question 11

stage3 NREM sleep

Answer 11

^) 4 Hz
2) Delta

Question 12

REM - sleep

Answer 12

1) Theta wave