Cerebral Physiology Flashcards
1
Q
Metabolic rate of braine
A
12_15% of cardiac output
2
Q
Cerebral blood flow (CBF)
A
50 ml/100 g/min
80% gray matter / 20% white matter
3
Q
How much of the brain energy consaption supports electrophysiologic function ?
A
60%
4
Q
Neurovascular coupling of brain
A
Increase cerebral activity (metabolism) ⇒ Increase CBF
5
Q
CBF autoregulated over MAP range
A
65-150 mmHg
6
Q
Chemical regulation of CBF
A
1) PaCO2 25-70 mmHg - CPF in normal range
2) If PaO2 less then 60 mmHg ⇒CBF increase dramatically
3) Reduction of body temperature ⇒suppression of cerebral metabolism
7
Q
Systemic vasodilatators and, CBF
A
Nstronglyarein, nitroprusside, hydroxyzine and Ca channel blockers ⇒vasodilate the cerebral circulation (depending on the MAP )
