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NEUROLOGY MODULE 8 > Cerebral Circulation,CSF and Ventricular System > Flashcards

Cerebral Circulation,CSF and Ventricular System Flashcards

0
Q

Who introduced the lumbar puncture in the year 1891?

A

Quincke

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1
Q

________ drain into dural venous sinuses which eventually empty into the internal jugular vein

A

CEREBRAL VEINS

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2
Q

He made the first correlations between disease processes and the cellular and chemical changes in the CSF

A

Mestrezat (1912)

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3
Q

TRUE or FALSE:

The CLASSIC MONOGRAPH on the CSF changes in all types of disease was published by Meritt and Fremont-Smith.

A

TRUE

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4
Q

The BASIS of our knowledge of CSF FORMATION, CIRCULATION & ABSORPTION was made by

A

Dandy and Weed (1935)

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5
Q

True or false:

Approximately 150 ml of CSF is in the spinal subarachnoid space

A

FALSE!

-approx “30 ml” of CSF is in the subarachnoid space

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6
Q

CSF Volume produced per day

A

About 500ml

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7
Q

Main site of CSF formation

A

Choroid plexus

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8
Q

True or false:

Choroid plexuses, located in the roof of the lateral, third and fourth ventricles are the main site of CSF formation

A

False.

Choroid plexuses, located in the FLOOR(not roof) of the lateral, third and fourth ventricles are the main site of CSF formation

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9
Q

Ave rate of CSF formation per hour

A

21-22 ml/hr(0.35 ml/min)

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10
Q

Which of the following statement is true about the diffusion of substances on thin walled vessels of the plexuses

A) it allows active diffusion of substances from the blood plasma into the extracellular space surrounding choroid plexus
B) it allows active diffusion of substances from the extracellular space into blood plasma surrounding choroid plexus
C) it allows passive diffusion of substances from the blood plasma into the extracellular space surrounding choroid plexus
D) it allows passive diffusion of substances from the extracellular space into blood plasma surrounding choroid plexus

A

C

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11
Q

Which of the ff statement is correct

A)electrolytes equilibrate with the CSF at all points in the ventricular and subarachnoid spaces
B) electrolytes equilibrate only with the CSF at all points in the subarachnoid space
C) electrolytes equilibrate with the CSF at all points in the ventricular but not in subarachnoid spaces

A

A

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12
Q

Transport of sodium is accomplish by the action of___________

A

Sodium-potassium-iom exchange pump

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13
Q

True or false:

Penetration of certain drugs and metabolites is in direct relation to their water solubility

A

False!

Penetration of certain drugs and metabolites is in direct relation to their LIPID solubility

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14
Q

Which of the ff statement about ionized compounds is true

A) hexoses and AA are relatively soluble to lipids
B) they enter the CSF faster
C)membrane transport system slows the entrance of ionized compounds in the CSF
D) ionized compounds are insoluble in lipids and enters the CSF Slowly

A

D

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15
Q

______ is formed by the tight junction(zona occludens) of capillary endothelial cells

A

BBB

16
Q

True or false

Anesthetics, psycho-active drugs and analgesics are permeable to BCB

A

False

BCB is permeable to water-soluble substances but not to lipo-soluble substances such as Anesthetics, psycho-active drugs and analgesics

17
Q

TRUE OR FALSE:

BBB is generally permeable to liposoluble substances(MW <500 daltons) but not to water-soluble substances

A

True

NOTE!!!!!
BBB- permeable to liposoluble subs but not to water sol. Subs
BCB- permeable to water-soluble subs but not to liposol.subs.

18
Q

2 lateral ventricles communicates with the 3rd ventricles through________

A

Interventricular foramen of monro

19
Q

Fluid passes from the 3rd ventricle through the__________ into the 4th ventricle

A

Cerebral aqueduct(of sylvius)

20
Q

________ contains the filum terminale and nerve roots of cauda equina

A

Lumbar cistern

21
Q

CSF CIRCULATION: pressure is highest in the_______ and diminishes successively along the _________

A

Ventricles; subarachnoid pathways

22
Q

This helps drive the fluid from the ventricular system

A

Arterial pulsations of the choroid plexuses

23
Q

Absorption of CSF is through the______

A

Arachnoid vill

24
Q

True or false:

Arachnoid villi penetrate the dura and protrude into the inferior sagittal sinus and other venous structures

A

False!

Arachnoid villi penetrate the dura and protrude into the SUPERIOR sagittal sinus and other venous structures

25
Q

Inhalation or retention of this substance which acts as a potent cerebral vasodilator causes inc ICP and l/t intracranial Hypertension

A

CO2

26
Q

T or F

Hyperventilation increases PCO2

A

False

note!!!!!!!
It decreases the PCO2 by inc pH and cerebral vascular resistance and thereby dec CSF pressure

This maneuver is used as treatment of acutely raised ICP

27
Q

If __________ are compressed, there is a rise of ICP that is transmitted to the lumbar subarachnoid space

A

Jugular veins

28
Q

_________ causes inc intra-thoracic pressure, which transmitted to the jugular and then to the cerebral and spinal veins

A

Valsalva maneuver

29
Q

A condition in which there is ventricular enlargement under tension as a result of an obstruction to the flow of CSF at some point in its ventricular pathway

A

Hydrocephalus

30
Q

Which is not correct about acute hydrocephalus

A) headache of varying gravity
B) drowsy or stuporous
C) bilateral babinski signs are the rule
D) congenital hydrocephalus

A

D

Congenital hydrocephalus is a clinical picture of CHRONIC HYDROCEPHALUS

31
Q

Clinical picture of acute hydrocephalus except

A) CNS infection
B) trauma
C) subarachnoid hemorrhage
D) type 2 chiari formation

A

D

Type 2 chiari formation is for chronic hydrocephalus

32
Q

CNS infection may involve:

A) leptomeninges and CSF spaces (meningitis)
B) ventricular system (ventriculitis)
C) spinal cord (myelitis)
D) A and B only
E) all of the above
A

E

NEUROLOGY MODULE 8 (1 decks)

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