Cerebral Circulation,CSF and Ventricular System Flashcards
Who introduced the lumbar puncture in the year 1891?
Quincke
________ drain into dural venous sinuses which eventually empty into the internal jugular vein
CEREBRAL VEINS
He made the first correlations between disease processes and the cellular and chemical changes in the CSF
Mestrezat (1912)
TRUE or FALSE:
The CLASSIC MONOGRAPH on the CSF changes in all types of disease was published by Meritt and Fremont-Smith.
TRUE
The BASIS of our knowledge of CSF FORMATION, CIRCULATION & ABSORPTION was made by
Dandy and Weed (1935)
True or false:
Approximately 150 ml of CSF is in the spinal subarachnoid space
FALSE!
-approx â30 mlâ of CSF is in the subarachnoid space
CSF Volume produced per day
About 500ml
Main site of CSF formation
Choroid plexus
True or false:
Choroid plexuses, located in the roof of the lateral, third and fourth ventricles are the main site of CSF formation
False.
Choroid plexuses, located in the FLOOR(not roof) of the lateral, third and fourth ventricles are the main site of CSF formation
Ave rate of CSF formation per hour
21-22 ml/hr(0.35 ml/min)
Which of the following statement is true about the diffusion of substances on thin walled vessels of the plexuses
A) it allows active diffusion of substances from the blood plasma into the extracellular space surrounding choroid plexus
B) it allows active diffusion of substances from the extracellular space into blood plasma surrounding choroid plexus
C) it allows passive diffusion of substances from the blood plasma into the extracellular space surrounding choroid plexus
D) it allows passive diffusion of substances from the extracellular space into blood plasma surrounding choroid plexus
C
Which of the ff statement is correct
A)electrolytes equilibrate with the CSF at all points in the ventricular and subarachnoid spaces
B) electrolytes equilibrate only with the CSF at all points in the subarachnoid space
C) electrolytes equilibrate with the CSF at all points in the ventricular but not in subarachnoid spaces
A
Transport of sodium is accomplish by the action of___________
Sodium-potassium-iom exchange pump
True or false:
Penetration of certain drugs and metabolites is in direct relation to their water solubility
False!
Penetration of certain drugs and metabolites is in direct relation to their LIPID solubility
Which of the ff statement about ionized compounds is true
A) hexoses and AA are relatively soluble to lipids
B) they enter the CSF faster
C)membrane transport system slows the entrance of ionized compounds in the CSF
D) ionized compounds are insoluble in lipids and enters the CSF Slowly
D
______ is formed by the tight junction(zona occludens) of capillary endothelial cells
BBB
True or false
Anesthetics, psycho-active drugs and analgesics are permeable to BCB
False
BCB is permeable to water-soluble substances but not to lipo-soluble substances such as Anesthetics, psycho-active drugs and analgesics
TRUE OR FALSE:
BBB is generally permeable to liposoluble substances(MW <500 daltons) but not to water-soluble substances
True
NOTE!!!!!
BBB- permeable to liposoluble subs but not to water sol. Subs
BCB- permeable to water-soluble subs but not to liposol.subs.
2 lateral ventricles communicates with the 3rd ventricles through________
Interventricular foramen of monro
Fluid passes from the 3rd ventricle through the__________ into the 4th ventricle
Cerebral aqueduct(of sylvius)
________ contains the filum terminale and nerve roots of cauda equina
Lumbar cistern
CSF CIRCULATION: pressure is highest in the_______ and diminishes successively along the _________
Ventricles; subarachnoid pathways
This helps drive the fluid from the ventricular system
Arterial pulsations of the choroid plexuses
Absorption of CSF is through the______
Arachnoid vill
