Cerebellum: Basic Circuitry Flashcards
After determining which parts of the brain are invovled and after establishing circuitry, what do we need to do?
Establish sites of plasticity- candidate sites from circuit details
Why do we want to know the cells where mossy fibre input (from the CS tone) and climbing fibre input (UCS shock or air puff) meet?
Synapses on these cells would be candidate sites for the plasticity underlying NMR conditioning
What is the cerebellum?
Little brain
Tight folds
Cerebellum has its own cortex
What are the two parts of the cerebellum?
Extensive cerebellar cortex
Compact deep nuclei
What does John Eccles 1967 work describe?
The structure of each of the cell types in the cerebellum
Their synaptic connections
Their electrophysiology
What is the cerebellar cortical circuitry?
Mossy fibres excite granule cells
Granule cell axons (parallel and ascending fibres) excite Purkinje cells
Purkinje cells inhibit cells in cerebellar nuclei
What is the first input to purkinje cells?
Mossy fibre inputs
What are mossy fibre inputs?
In the case of NMR conditioning these fibres convey information about the tone (CS) to area HVI
Frequency of firing increases with tone intensity
What are granule cells?
Mossy fibres synapse with granule cells
The axons of granule cells form parallel fibres, that synapse with the dendrites of Purkinje cells
How many granule cells are there?
There are very many granule cells - ~80% of all neurons in the human brain
At least 100 per mossy fibre, hence “expansion recoding”
What are the three layers of the cerebellar cortex?
Molecular layer (top)
Purkinje layer (middle)
Granule layer (bottom)
What are purkinje cells?
Purkinje cells bodies lie in the middle (purkinje cell) layer
Largest cell in cerebellar cotex with distinctive dendritic field
Sole output cells of the cerebellar cortex- output comes out through axons of purkinje cells and these travel back down through the granular layer into the white matter
Each purkinje cell receives 150,000 parallel fibre synapses
What is in the molecular layer of the cerebellar cortex?
Parallel fibres and dendrites of purkinje cells
What is in the granule layer or the cerebellar cortex?
Small granular cells
What are golgi cells?
Get input from parallel fibres
Project back to the synapses between mossy fibres and granule cells
Are golgi cells inhibitory?
Yes
The more parallel fibre input they get the more they reduce it
What is the presumed function of golgi cells?
Control expansion recoding
What is expansion recoding?
Not quite known fully
Believed to be part of the machinery that ensures that information arising at the synapses is in a suitable form
What are two additional cell types in the molecular layer of the cerebellar cortex?
Stellate cells
Basket cells
Both get input from parallel fibres
Both inhibitory