Cerebellum

Question 1

Mention most common cytogenetic aberration of medulloblastoma

Answer 1

Loss of short arm with long arm duplication of ch17 forming isochromosome 17q

Question 2

Describe the most favourable variant

Answer 2

WNT-activated, rarest molecular subtype recognized by nuclear beta-catenin

Question 3

Hemangioblastoma may occur in association with …….

Answer 3

Von Hippel-Lindau disease

Question 4

Describe gross picture of hemangioblastoma

Answer 4

60% well circumscribed, partly cystic, highly vascularized lesions, 40% completely solid
Occasionally yellow due to lipid content
Cyst with solid vascular nodule that abut a pial surface

Question 5

Describe microspcopic picture of hemangioblastoma

Answer 5

Two main components 1. Neoplastic stromal cells characteristically large & vacuolated 2. Abundant vascular cells
Thin walled vessels
Intratumoral hemorrhage