Cerebellar System And Ataxia Flashcards
Give an example of heridetary cerebellar ataxia with autosomal dominant inheritance?
Spinocerebellar ataxia SCA
What are the five hereditary cerebellar ataxia is with autosomal recessive inheritance
1)friedreich’s ataxia
2)ataxia-telangiectasia
3) Ataxia associated with vitamin E deficiency
4) Ataxia oculomotor apraxia
5) Ataxia associated with coenzyme Q 10 deficiency 
Which genetic mutation is involved in friedreich’s ataxia?
GAA trinucleotide repeat in frataxin gene
What is the mortality cause in Friedreich’s ataxia?
Cardiac involvement
What are the clinical findings observed in Friedreich’s ataxia?
Scoliosis, pes cavus, cardiomyopathy, diabetes myelitis and deafness
What is the most common recessive ataxia accompanied with sensory findings and a reflexia due to degeneration of the posterior cord and dorsal root ganglia on?
Friedreich’s ataxia
What is the definitive diagnosis in Friedreich’s ataxia
Genetic testing
What are the causes of acquired ataxia with chronic course?
1) Alcoholic cerebellar degeneration
2) Vitamin E deficiency
3) New variant Creutzfeldt-Jakob disease 
4) Chronic inflammatory demyelinating polyneuropathy (CIDP)
What are the causes of acquired ataxia with acute or subacute onset?
What is dysarthria
Synergy between muscles that provide speech function is impaired; pt speaks as if drunk
What is tremor what does it occur asa result from?
In cerebellum diseases, it occurs during coordinated movement
What is ataxia
What is hypotonia in cerebellum lesion
Loss of tonus affecting ipsilateral side of cerebellar hemisphere
Ataxia in midline lesions of the cerebellum is referred to as what?
Trunk ataxia in which the patient has difficulty understanding and working
Is hypotonia answerable and lesions ipsilateral or contralateral?
Hypotonia is observed in the arm and leg on the same (ipse lateral) of affected cerebellar hemisphere
What is sensory ataxia
The …….. is associated with the ipsilateral side of the body
,While the ……….. is associated with the contralateral side
1-cerebellum
2-cerebral cortex
Vertigo, nystagmus, and ataxia occur in lesions of which part of the CNS?
In lesions of vestibular part of cerebellum (archi-cerebellum)
What are the clinical findings in cerebellum lesions?
Ataxia(sensory or vestibular)
Tremor
Dysmertia
Dysarthria
Hypotonia
Dyssynergia
Dysdiadokinesia
Which of the following has extremity involvement ; hemispheric, vestibular or vermis?
Sensory ataxia occurs due to which lesion?
**Where is the lesion observed in vestibular ataxia?
In Nucleus vestibularis and its central connections
1+ Lesions in the ………produce limb (appendicular) ataxia.
2+Lesions of the ……. cause truncal and gait ataxia (NOT affecting the limbs, & NO dysmertia and Dysdiadokinesia.)
3+…… lesions cause disequilibrium, vertigo, and gait ataxia.
1+CEREBELLAR HEMISPHERE
2+ VERMIS[mid-line]**
3+VESTIBULOCEREBELLAR
