Cephalospornis

Question 1

1st generation ( beta-lactamase resistance)

Answer 1

cephalexin
cefazolin

mechanism of action :
bactercidal inhibits cell wall mucopeptide synthsis

clinical application:
primary gram -
moraxella , neisseria, salmonella and shigella
anaerobic bacteria
respiratory tract infections
- H influenzae

avoid use
gram-positive

Side effects:
Neutropenia, thrombocytopenia steven johnson syndrome may elevate INR

Question 2

2nd generation

Answer 2

cefotetan
cefuroxime

mechanism of action
bactercidal inhibits cell wall mucpeptide synthesis

clinical application
activity against gram -
morxella , miesseria , samonella and shigella
anerobi bacteria
respiratory trac infections
H infulenzia

avoid use
gram + bacteria
side effects
neutropenia, thrombocytpeina, steven johnson syndrome may elevate INR

Question 3

3 rd generation

Answer 3

ceftriaxone
ceftazidime

mechanism of action
bactercidal inhibits cell wall mucopepetide syntheis

clinical application
gram neg organism
multisystem coverage
CAP
intrabdominal
UTI
meningitis
nosocomial infections

avoid
listeria, entercocci , MRSA , pseudomonas aerguinosa , bacteroides species

side effecs
simular
drug interaction PPI , QT prolongation

Question 4

4th generation

Answer 4

cefepime

mechanism of action
bacterialcidal , inhibits cell wall mucopeptide synthesis

Clinical application:
activity against both gram - and +
p aeruginous
enterobactercicie
MSSA
anaerobic coverage
inta abdominal
respiratory tract
skin infections
neutropenic fever

avoid use
ESBL
side effects
simular

Question 5

5th generation

Answer 5

ceftaroline