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Cephalosporins Differentiation Flashcards

1
Q

Cefadroxil

A

1st generation Cephalosporin

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2
Q

Cephalexin

A

1st generation Cephalosporin

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3
Q

Cephradine

A

1st generation Cephalosporin

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4
Q

Cefazolin

A

1st generation Cephalosporin

  • only available in parenteral formulations and it is widely used in peri-operatively to prevent infections post-surgery.
  • preferred drug for surgical prophylaxis.
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5
Q

Cefaclor

A

2nd generation Cephalosporin

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6
Q

Cefuroxime

A

2nd generation Cephalosporin

  • the only 2nd gen. to cross BBB. However, less effective than ceftriaxone in meningitis and it is not used.
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7
Q

Cefprozil

A

2nd generation Cephalosporin

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8
Q

Cefoxitin

A

2nd generation Cephalosporin

  • moderate activity against anaerobes.
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9
Q

Cefotetan

A

2nd generation Cephalosporin

*moderate activity against anaerobes.

  • it contains N-Methylthiotetrazole (MTT) side chain.

> inhibits vitamin K production and may prolong bleeding

> cause disulfiram-like reaction if co-administered with ethanol

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10
Q

Cefmetazole

A

2nd generation Cephalosporin

*moderate activity against anaerobes.

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11
Q

Ceftriaxone

A

3rd generation Cephalosporin (Parenteral)

  • adult dose: 1-2 g/day once or every 12 hours.
  • DON’T mix Ceftriaxone and calcium-containing products e.g. Ringer’s Solution.
  • Excretion is through biliary duct; no dose adjustment in renal insufficiency.
  • Along with Cefazolin, used in surgical prophylaxis.
  • Not used in premature neonates and hyperbilirubinemia; displaces bilirubin.
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12
Q

Cefotaxime

A

3rd generation Cephalosporin (Parenteral)

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13
Q

Cefoperazone

A

3rd generation Cephalosporin (Parenteral)

  • along with Ceftazidime, they are the only ones with Anti-pseudomonal activity
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14
Q

Ceftazidime

A

3rd generation Cephalosporin (Parenteral)

  • TAZ = Pseudomonas Killer (along with Cefoperazone)
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15
Q

Cefixime

A

3rd generation Cephalosporin (Oral)

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16
Q

Cefdinir

A

3rd generation Cephalosporin (Oral)

  • Avoid using iron supplements within 2 hours before or after taking Cefdinir.
17
Q

Cefpodoxime

A

3rd generation Cephalosporin (Oral)

18
Q

Cefditoren

A

3rd generation Cephalosporin (Oral)

19
Q

Cefepime

A

4th generation Cephalosporin

20
Q

Cefpirome

A

4th generation Cephalosporin

21
Q

Cefobiprole

A

5th generation Cephalosporin

22
Q

Ceftaroline

A

5th generation Cephalosporin

  • used w/ Fosamil
23
Q

Ceftolozane

A

5th generation Cephalosporin

  • used w/ Tazonactam

Cephalosporins (1 decks)

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