Cephalosporins

Question 1

name 1st generation Cephalosporins

Answer 1

Cefazolin 
Cefadroxil
Cehalexin
Cephalothin
Cephapirin
Cephradine

Question 2

What do all first generation cephalosporins treat

Answer 2

PeCK
Proteus mirabilis
K. pneumonia
E. coli

Question 3

Name 5 bacteria fist generation Cephalosporins do NOT treat

Answer 3

P. aeruginosa
Enterobacter
S. marcescens
Citrobacter
Acinetobacter
B. Fragilis

Question 4

DOC for surgical prophylaxis

Answer 4

Cefazolin

Question 5

first gen cephalosporin DOC for E.coli & K. pneumonia

Answer 5

Cefazolin

Question 6

What can Cefazolin NOT treat

Answer 6

meningitis

Question 7

1st generation cephalosporin alternate to anti-staph treatment in pts with penicillin allergy

Answer 7

Cefazolin

Question 8

Only first generation IV or IM

Answer 8

Cefazolin

Question 9

what are 1st gen ceph used to treat

Answer 9

UTI
Strep & Staph infection
Cellulitis
Soft tissue abscess

Question 10

Name 3 IV 2nd gen Cephalosporins and what they treat

Answer 10

Cefotaxime
Ceftazidime
Ceftrixone
* active against B. fragilis & less active against H. Influenzae

Question 11

2nd generation cephalosporin used with penicillin-non-succeptible pnemocci

Answer 11

Cefuroxime axetil

Question 12

which 2nd generation cephalosporin has greater susceptibility to B-lactamase hydrolysis

Answer 12

Cefaclor

Question 13

Clinical use of 2nd gen cephalosporins

Answer 13

H. Influenza or Moraxella catarrhalis

- sinusitis, otitis, lower respiratory tract infection

Question 14

Peritonitis, Diverticulitis, & Pelvic Inflammatory Disease is treated with what 3 cephalosporins

Answer 14

2nd generation -

1. Cefoxitin
2. Cefmetazole
3. Cefotetan

Question 15

Which 2nd generation cephalosporin is used to treat community acquired pneumoniae

Answer 15

Cefuroxime

Question 16

Cefuroxime crosses the BBB but is less effective than what 2 drugs in treating meningitis?

Answer 16

Ceftriaxone
Cefotaxime
*3rd gen cephalosporins

Question 17

What do 3rd gen cephalosporins treat

Answer 17

Citrobacter
S. marcesens
Providencia

Question 18

What are 3rd gen cephalosporins not good to treat

Answer 18

Enterobacter

Question 19

3rd generation cephalosporins used to treat P. aeurginosa

Answer 19

Ceftazidime

Ceoperazone

Question 20

3rd generation cephalosporins used to treat B. fragilis

Answer 20

Ceftizoxime

Moxalactam

Question 21

What 3rd gen cephalosporins are not good for S. aureus

Answer 21

Cefixime and Ceftibuten

Question 22

What do Ceftriaxone and Cefotaxime treat

Answer 22

meningitis & most active against penicillin non-susceptible strains of pneumococci

Question 23

What meningitis will Ceftraixone and Cefotaxime NOT treat

Answer 23

caused by L. monocytogens

Question 24

Neutropenic, Febrile immunocompromised patietn is best treated with what 3rd gen cephalosporin

Answer 24

Ceftazidime

Question 25

Name 4th gen cepholosporins

Answer 25

Cefepime

Question 26

What does Cefepime treat

Answer 26

P. aeruginosa
Enterobacteriacea
S. aeureus
S. pneumonia

Question 27

What is Cefepime highly active against

Answer 27

Haemophilus

Neisseria

Question 28

T/F Cefepime penetrates cerebral fluid

Answer 28

true

Question 29

what is used to treat MRSA

Answer 29

ceftaroline fosamil - this drug is bactericidal

Question 30

Adverse effect specific to cephalosporins

Answer 30

Hypothombinemia & Bleeding disorders assoc with Cefamandole, Cefmetazole, Cefotetan, Cefoperazone

–> also a disulferam reaction when taken with alcohol

Question 31

What can a patient take to prevent Hypothombinemia & bleeding dz assoc w. the specific cephalosporins

Answer 31

Vitamin K