Cephalosporins Flashcards
1st gen
cefazolin (IV, IM)
cephalexin
2nd gen
Cefuroxime
Cefoxitin (2i)
Cefotetan
3d gen
Group 1:
Cefdinir
Ceftriaxone
Cefotaxime
Group 2 :
Ceftazidine
4th gen
Cefepime
5th gen
Ceftaroline (caroline the white girl)
Combinaisons
Ceftazidime/Avibactan (avycaz)
Ceftolozane/tazobatan (zerbaya)
Used for : Surgical ppx
cefazolin
cefoxitin + cefotetetan (GI procedures)
Used for: MDR Gram neg (including pseudomonas)
Combinaisons cephalo
Used for : Skin infections (MSSA) + Strep throat
Cephalexin
Used for : CAP + SSTI
Ceftaroline
(only beta-lactam active against MRSA)
Used for : Acute otitis media
Cefuroxime (used for CAP pneumonia too)
cefdinir
Used for : active against pseudomonas
cefepine
ceftazidime
Used for : anaerobic coverage (B fragilis)
Cefoxitin
Cefotetan
(and used for GI procedures too)
Used for : CAP
Cefuroxime
Ceftriaxone
Cefotaxime
Used for :
Meningitis
Pyelonephritis
Spontaneous bacterial peritonitis
ceftriaxone
cefotaxime
and used for CAP too
Inpatients/outpatients : Cefazolin
in
Inpatients/outpatients : Cephalexin
out
Inpatients/outpatients : Cefuroxime
out
Inpatients/outpatients : cefoxitine
in
Inpatients/outpatients : cefotetan
in
Inpatients/outpatients : cefdinir
out
Inpatients/outpatients : ceftriaxone + cefotaxime
in
Inpatients/outpatients : ceftazidine
in
First gen covergage
Strep
MSSA
PEK
(cefazolin, cephalexin)
Second gen converage
MSSA
More resistant S. pneumoniae
HNPEK
Gram neg anaerobes (B. fragilis) = cefotetan
Third gen group 1 coverage
Resistant strep + HNPEK
MSSA
Gram + anaerobes
Third gen group 2 coverage
No GRAM +
pseudomonas
Fourth gen coverage
Same Gram + as ceftriaxone
HNEPK
CAPES
Pseudomonas
Fifth gen coverage
Same Gram neg as ceftriaxone
Broad Gram +
MRSA
Cefotetan with alcohol ingestion
Can cause disulfiran like rxn
Dosage Cephalexin
PO : 250-500 mg q6-12h
Particularities : ceftriaxone + cefotaxime
No renal dose adjustment
Do not use in neonates
Coverage MSSA
1/2/3 gen
Coverage HNPEK
2d gen
4th gen
And PEK 1st gen