Central Visual Pathways and Vision Flashcards

1
Q

What is the normal visual pathway?

A
Eye
Optic nerve
Optic chiasm
Optic tract
Lateral geniculate nucleus
Optic radiation
Visual cortex
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2
Q

How is an image seen by our eye?

A

An inverse image

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3
Q

Describe how the light travels into the eye and get transformed into electrical energy.

A

Light is focused by cornea and lens
Traverses the vitreous humour
Travels through layers of retinal neurons
Before reaching photoreceptors

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4
Q

What are the different types of photoreceptors?

A
Rods
Not present in central retina
Photosensitive
Dark adapt
Many rods converge into one single bipolar cell
Cones
Concentrated in fovea
High acuity
Day vision
Colour vision
Three types of cones (blue, red, green)
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5
Q

What are the different classes of neurons in the retina?

A

The retina has three major functional classes of neurons

Photoreceptors (rods, cones)

Interneurons (bipolar, horizontal and amacrine cells)
Combining signals from photoreceptors

Ganglion cells
Magnocellular (M) and parvocellular (P)

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6
Q

What are the different sensitivities of the different ganglion cell pathways of the retina?

A
Stimulus features : Magnocellular \/ Parvocellular 
Colour contrast : No \/ Yes
Luminance Contrast : Higher \/ Lower
Fine detail : lower \/ higher
Motion : Higher \/ Lower
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7
Q

Tell me about the optic chiasm.

A

Axons from ganglion cells pass through optic disc to optic nerve and optic chiasm

Fibres from nasal retina cross to opposite site of brain

Temporal axons from ganglion cells do not cross

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8
Q

What is the fovea?

A

A depression in the back of the eye, with a high concentration of cones
It is opposite the lens and is responsible for sharp vision in the centre of your visual field.

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9
Q

Tell me about the optic tract.

A

Right optic tract
Fibres from right half of each retina
Responsible for the left hemifield of the visual field

Left optic tract
Fibres from left half of each retina
Responsible for the right hemifield of the visual field

The optic tracts are from the optic chiasm

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10
Q

Tell me about the lateral geniculate nucleus (LGN).

A

90% of retinal axons terminate in lateral geniculate nucleus (part of thalamus)

Major input to LGN from other centres
(Reticular formation, brain stem, cortex)
Feedback connections

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11
Q

Tell me about the primary visual cortex.

A

Each half visual field is represented in contralateral primary visual cortex

Each half of the visual field is split into 6 sections

The inner sections, where the fovea picks up the light, has the largest amount of neurones and space of brain, and so gives a sharper image than the rest.

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12
Q

Tell me about the ventral and dorsal pathways.

A

P pathway > ventral stream > V2 and V4 > inferior temporal cortex (Object recognition and colour)

M pathway > dorsal stream > V3 and V5 > Posterior parietal cortex (object location and motion)

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13
Q

How does vision develop?

A

New born can barely see anything
At 4 weeks slightly better, very general idea of shapes
8 weeks slightly better again, better shape recognition
3 months, much sharper image
6 months better colour and sharper

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14
Q

What is amblyopia?

A

Lazy eye caused by abnormal binocular input early in life

Strabismus (having a squint)

Anisometropia (refractive difference between the two eyes)

Deprivation (congenital cataract, ptosis, media opacities)

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15
Q

What are the different types of strabismus?

A

Esotropia (one eye goes inwards compared to the other)

Exotropia (One eye goes outwards)

Left Hypertropia (One eye goes upwards) (left eye)

Left Hypotropia (one eye goes downwards) (left eye)

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16
Q

What is anisometropia?

A

Uncorrected difference in refractive power between the two eyes

It causes amblyopia

Emmetropia: light focuses on the retina

Myopia: Focus in front of retina

Hyperopia: Focus behind retina

17
Q

What are the treatment options for amblyopia?

A

There is plasticity in the brains of children
So glasses and patching can improve vision in first years of life
Treatment is possible but often not successful because of poor compliance

18
Q

What is the optic disc?

A

Ganglion cell axons exit, has no photoreceptors

19
Q

How does glaucoma happen?

A

High intraocular pressure
Damage to optic nerve
peripheral visual field defect (often not noticed)

20
Q

What happens in a lesion of the optic chiasm?

A

There is a bi temporal visual field defect
Peripheral blindness in both eyes
Often caused by a pituitary adenoma

21
Q

What is the pathway for pupil constriction?

A

Light is detected by optic nerve
Then it travels and synapses in the pretectal nucleus in the superior colliculus
Then these neurons synapse with efferents of the oculomotor nerve in the Edinger-Westphal nucleus
Of both sides
These efferent then travel to the ciliary ganglion where they synapse with the nasociliary nerve which innervates the pupil and constricts it.

Due to both sides being connected to each sided oculomotor nerve, you get consensual constriction

22
Q

What is Horner’s syndrome?

A

Miosis: Pupil small because sympathetic nerve innervated dilator pupillae
Ptosis (2-3mm) Müller’s muscle paretic
Anhydrosis: lack of sweating of same side of face (Sudomotor fibres)