Central nervous system head - part 2 Stroke Flashcards

1
Q

What are the causes of stroke

A
A) Infarction 75%
- unknown 50%
- lacunar 25%
- embolic 20%
- artherosclerosis 5%
B) Hemorrhagic 25%
- intracerebral 50%
- subarrachnoid 50%
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2
Q

How to rule out stroke mimic from real stroke

Stroke screening tool

A

ROSIER Tool
Rule Out Stroke In the Emergency Room

Rosier scale to differentiate stroke and "stroke mimics"
1) Has there been loss of consciousness or syncope 
 yes -1 , no 0
2) Has there been seizure activity 
yes -1,  no 0
Is there a new onset (or waking from sleep)?
- relate to onset
i) Asymmetric facial weakness
Y (+1)  N (0)  
ii) Asymmetric arm weakness
Y (+1)   N (0)  
iii) Asymmetric leg weakness
Y (+1)  N (0)  
iv) Speech disturbance
Y (+1)  N (0)  
v) Visual field defect
Y (+1)   N (0)  

Stroke is likely if total score > 0

Scores of < / = 0 have low probability of stroke but not excluded

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3
Q

Most common Stroke mimics

A
  • Seizures 21% - common in elderly with previous stroke
  • Sepsis 13%
  • Toxic/ metabolics - 11% likehypoglycemia, drugs, hypoxia, hyponatremia
  • Space ocupying lesion 9%
  • Syncope and presyncope 9%
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4
Q

What are other stroke mimics

A
  • migraine
  • Subdural hematoma
  • Herpes encephalitis
  • Psychogenic
  • Aortic disection
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5
Q

What are the feature of Middle cerebral artery syndrome

A

a) contralateral hemiplegia and hemisensory loss
b) homonymous hemianopia
c) eye deviate to side of the leson
d) face and arm weakness > legs

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6
Q

What are the feature of the Anterior cerebral artery syndrome

A

a) contralateral leg and foot weakness
b) behavioural disturbnce + confusion
c) abulia
d) grasp reflex
e) urinary incontinence

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7
Q

What are the feature of the posterior cerebral artery syndrome

A

a) eye - hemianopia or quadrantanopia or cortical blindness
b) Memory loss
c) dyslexia
d) Hemisensory loss
e) ipsilateral 3rd nerve palsy

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8
Q

What are the feature of vertebrobasilar infarction

A

a) ataxia and dizziness
b) nystagmus, nausea and vomiting
c) variety of cranial palsy eg interneuclear opthalmoplegia

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9
Q

What is a lacunar infarct

A
  • Small infarct in distribution of short penetrating aterioles of - basal ganglia, pons, cerebellum anterior limb of the internal capsule or deep cerebtral white matter
  • account for 15% of all cerebral infarct
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10
Q

what is clincal syndrome of Lacunar infarct

A
  • lesion in mid pons - clummsy hand / dysarthria
  • lesion pons or internal capsule - Ataxia and leg paresis
  • Thalamic - pure sensory - face, arn and leg
  • pons / internal capsule - pure motor hemiplegia ( Arm more than legs)
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11
Q

What is theassociated factors, management and prognosis of Lacunar infarct

A
  • associated with poorly controlled hypertension and diabetes
  • rarely have prodromal TIA
  • good prognosis and management is aimed at controlling BP and normalising sugar
  • Partial or complete recovery over 4 to 6 weeks
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12
Q

What are the different type of Stroke Assessment scale

A

1) Stroke deficit scale - NIH or Canadian neuro scale
2) Mental status screening test - MMSE,
3) Language scales - Boston diagnostic aphasia, ASHA
4) Depression scales - Geriatric depression scale
5) ADL scales - Barthel index, FIM, PGC instrumental activities of daily living

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13
Q

What are the features of Cerebral infarction in CT

A
  • Parenchymal hypodensity
  • Loss of grey white differentiation
  • effacement of cortical sulci
  • local mass effect
  • Obscuration of the lentiform nucleus
  • Hyperdense middle or other cerebral artery
  • 100% specificity, 50% sensitivity for MCA occlusion
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14
Q

What are CT features of poor outcome

A
  • Cortical hypodensity in >1/3 of MCA teritory
  • sulcal effacement
  • mass effect
  • cerebral oedema
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15
Q

Describe your initial resuscitation of a patient who present with a stroke to your ED with regard to airway and breathing

A

NB hypotension, hypertension, hyperglycemia, fever, hypoxia - are associated with poor outcome

A) Airway - 1) simple measure - positioning/ oral or nasal airways

  • prepare to intubate if good outcome likely and simple measures above failing
    2) NGT if poor gag reflex

B) Breathing - supplementary oxygen if the O2 sat < 95% ( aim 99 to 100%)

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16
Q

Describe your initial resuscitation of patient with stroke with regadr to circulation

A

C) Circulation - BP > 180 by 10mmhg - 40% neurological damage and poor outcome in 23%

  • hypotension - fluid + pressor - target >100/>70mmhg
  • hypertension - not thrombolyse treat if > 220/120mmhg
  • hypertension for thrombolysis treat >180/110mmhg
17
Q

What are your options for management of high BP in stroke patient

A

1)Labetolol - load 10mg IV
start infusion at 2mg /min - up to 8mg /min
2) alternative Nicardipine 20mg load
3) or nitroprusside infusion

18
Q

With regard to NINDs trial for stroke thrombolysis - what are the weakness and criticism of this trial

A

1) Imbalance of stroke severity between the 2 groups
2) Selective enrolment to artificially increase number of patients treated early
3) Success found at 3 months can be due to no control over post thrombolytic therapy
4) No comparison of the medians of the NIH stroke score published

19
Q

ECASS studies results

A

ECASS II - No satistical significant difference between tPA and placebo group at 30days and 90 days
- tPA had higher incident of ICH and Cerebral oedema

ECASS III - global outcome score showed benefit tPA over placebo ( a new combined score)
- High incidence of ICH with tPA
- overall mortality no satistically significant
( again criticism of selection bias)

20
Q

What are the contraindications for Thrombolysis

A
  • timing - unknown or > 4.5hrs
  • BP - > 185/110mmhg
  • spontaneous rapid improvement of symptoms
  • minor or isolated neurological signs
  • major neurological deficit
  • High risk CT findings
  • seizure
  • platelet 15s
    glucose < 2.7 >22.2mmol/L
21
Q

Tests required prior to Thrombolysis

A
  • Head CT
  • FBC
  • U&E, CR
  • Clotting
  • Glucose
  • ECG
  • CXR
22
Q

What is tPA administration requirement

A
  • must comence within 3 hrs of onset
  • dose 0.9mg/kg ( max 90mg) - 10% bolus, 90% over 60min
  • no anticoagulation or antiplatelet agents for 24 hrs
23
Q

What are the aftercare for thrombolysis patient

A
  • Require specialised stroke beds or HDU for increase care required
  • BP monitor and control
  • Every 15min 1st 2 hrs
  • every 30 min next 6hrs
  • every hour for next 16hrs