Central Nervous System drugs Flashcards
It is study of drugs that alter processes controlled by the nervous system.
NEUROPHARMACOLOGY
It is a type of neurotransmission in which information is carried across the gap between neuron and postsynaptic cell.
Synaptic Transmission
Conducting an action potential down the axon of the neuron
Axonal Conduction
Drugs that is used for psychiatric disorders, suppression of seizures, relief of pain, production of anesthesia.
CNS DRUGS
It Impedes or blocks the entry of drugs into the brain where passage is limited to lipid-soluble agents or via specific transport systems.
BLOOD BRAIN BARRIER
true or false
CHILDREN are much more sensitive to CNS drugs than adults.
TRUE
State in which abrupt discontinuation of drug use will precipitate a withdrawal syndrome
Physical Dependence
Give 2 Characteristics of ADHD (Attention Deficit/ Hyperactivity Disorder).
inattentiveness, inability to concentrate, restlessness, hyperactivity, inability to complete tasks and impulsivity
It is described as falling asleep during normal waking activities (driving/ talking), unable to move, and may collapse.
NARCOLEPSY
It affects the extrapyramidal system which influences movement and it is a slowly progressive neurodegenerative disorder characterized by tremor, rigidity, postural instability, and slowed movement
PARKINSON’S DISEASE
Dopaminergic drugs are…
directly/ indirectly cause activation of dopamine receptors
Type of seizure which excitation undergoes limited spread from the focus to adjacent cortical areas
PARTIAL SEIZURES
Type of seizure which excitation spreads widely throughout both hemispheres of the brain
GENERALIZED SEIZURES
Most commonly prescribed anticonvulsant drug
PHENYTOIN
A drug that is effective against partial seizures and generalized tonic-clonic seizures but not absence seizures
PHENOBARBITAL
It is an involuntary contraction of a muscle or muscle group, often painful, and decreases the level of functioning.
MUSCLE SPASM
Most effective drug for spasticity of cerebral origin [i.e. cerebral palsy, MS, spinal cord injury, stroke]
DANTROLENE SODIUM
It relaxes skeletal muscle by disrupting the transmission of nerve impulses at the motor end plate.
NEUROMUSCULAR BLOCKING DRUGS
Give 2 uses of NON DEPOLARIZING AGENTS
Ease of passage of an endotracheal tube
Decrease the amount of anesthetic required during surgery
Facilitate realigning broken bones and dislocated joints
Prevent muscle injury during ECT
It acts like acetylcholine but not inactivated by ACHe, DOC for short procedures (less than 3 minutes) and for orthopedic manipulations.
Succinylcholine
