Central Nervous System Depressants

Question 1

central nervous system

Answer 1

brain and spinal cord

Question 2

3 cs of addiction

Answer 2

• compulsivity:
• control
• consequences

Question 3

compulsivity

Answer 3

what happens before use

Question 4

control

Answer 4

what happens after use, difficult to control

Question 5

consequences

Answer 5

outcomes, negative

Question 6

protecting the supply

Answer 6

being controlling of drug supply

Question 7

dependence

Answer 7

can be psychological and physiological

Question 8

tolerance

Answer 8

need for increased intake for desired effect

Question 9

reverse tolerance

Answer 9

intoxication after small doses due to liver damage

Question 10

potentiate

Answer 10

combined effect of drugs is greater than effects of each drug alone

Question 11

cross-tolerance

Answer 11

tolerance to all drugs in a category

Question 12

drug half-life

Answer 12

time it takes for half of drug to be metabolized

Question 13

cross-addiction

Answer 13

addiction to drugs across categories

Question 14

effective dose

Answer 14

(ED) dose at which the average person will respond

Question 15

lethal dose

Answer 15

(LD) dose at which average person would die from use

Question 16

therapeutic window/index

Answer 16

a ratio of the effective does and lethal dose

Question 17

agonists

Answer 17

mimic neurotransmitters

Question 18

antagonists

Answer 18

block receptor sites

Question 19

partial agonists

Answer 19

combination of agonists/antagonists

Question 20

spring effect of withdrawal

Answer 20

withdrawal creates opposite effect of drug

Question 21

general effects of depressants

Answer 21

slurred speech, disorientation, drunkenness, relaxed inhibitions

Question 22

general effects of depressant withdrawal

Answer 22

anxiety, insomnia, tremors, delirium, convulsions, possible death

Question 23

general effect of depressant overdose

Answer 23

shallow respiration, cold/clammy skin, dilated pupils, weak and rapid pulse, coma, possible death

Question 24

5 depressant substance types

Answer 24

• alcohol
• sedative-hypnotics
• barbiturates
• benzodiazapines
• anxiolytics

Question 25

proof

Answer 25

measure of alcohol content, 2X the alcohol content

Question 26

high liver enyzmes

Answer 26

indicates likelihood of heavy drinking

Question 27

BAL/BAC

Answer 27

milligrams of alcohol per 100 liters of blood (mg/ml), .08-.10% usually legal limit in most states, .3% passed out, .6% usually lethal