Central Dogma Of Molecular Biology Flashcards
Differs between replication and transcription
1) type of nucleic acid
2) length of NA
3) enzymes envolved
4) phase of cell cycle
Which cells are resting cells
Non-dividing cells. They are most of the cells. They are in a G0 phase
What is gene expression
Transcription + translation
When does gene expression occurs
During the entire interphase. Doesnt occur in mitosis
Drugs that target S phase
5-fluorouracil
Methotreaxate
Which protein does 5-fluorouracil block
Thymidylate synthase
Which protein does methotraxate block
Dihydrofolate reductase
Which drug targets to G2 phase
Bleomycin
What can bleomycin cause
Pulmonary fibrosis
Which drugs target mitosis
Paclitaxel (depolymerase microtubes)
Vincristine, vineblastine (bind to the microtubular proteins)
Both interfere the mitosis spindle formation
Non cell-cycle specific drugs
Cyclophosphamide
Ciplastin
Gene expression and DNA replication comparison
What is gene
Its a unit of DNA that encodes a particular protein or RNA molecule
Who controls the cell cycle
Cyclins by activating cyclin-dependent kinases. They ensure that cells will not enter the next phase untill all the molecular events of the previous phase are concluded.
