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Bio300 > Cellulsr replication And MTs (topic5) > Flashcards

Cellulsr replication And MTs (topic5) Flashcards

1
Q

E2F

A

Transcription factor of S phase required proteins

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2
Q

Rb

A

Inhibits E2F

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3
Q

CyclinD

A
  • activated by ras/MAPK

- activates G1 cyclin/cdk

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4
Q

G1 cyclin-cdk

A

Phosphorylates Rb, Rb dissociates from E2F

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5
Q

Sic1

A

Bind S phase cyclin/cdks

Also target for G1 cyclin/cdks (degradation)

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6
Q

ORC

A

Origin recognition complex

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7
Q

Cdc6, cdt1

A

Load mcm helicase when unphosphorylated

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8
Q

S-phase cdk

A

Phosphorylates pre replication complex factors (vdec45gin) and cdc6, cdt1

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9
Q

Cdc14

A

Phosphotase, destructs S phase cyclin/cdk in anaphase (mcm can be reloaded)

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10
Q

Cdc25

A

Phosphotase, removes inhibitory phosphate on mcdk

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11
Q

Kleisin

A

Links monomers of SMC proteins

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12
Q

SMC proteins

A

Assist in DNA condensation and cohesion

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13
Q

Condensin

A

Phosphorylation by m cyclin/cdk cross links DNA

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14
Q

Cohesin

A

Surrounds chromosomes, attached in G1. Phosphorylation by m cyclin/cdk causes dissociation except at centromere

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15
Q

Phosphotase PP2A

A

Prevents phosphorylation of Cohesin at centromere

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16
Q

APC

A

Involved in cleavage of Cohesin through activation of securin and attachment of kinetochore through activation of cdc 20

Also targets m-cyclin cdk for destruction

17
Q

Separase

A

Cleaves Cohesin when released from securin

18
Q

Mad/bub

A

Attached to unbound kinetochores, prevents activation of cdc20

19
Q

Cdc20

A

Involved in separation of chromosomes, activated by APC and dissociation from mad/bub

20
Q

Cdh1

A

Directs APC to target m cyclins

21
Q

Cdc14

A

Removes inhibitory phosphate from cdh1 and phosphates added by m cyclin cdk

Phosphotase, destructs S phase cyclin/cdk in anaphase (mcm can be reloaded)

22
Q

M cyclin cdk

A 
Activated by cdc25
Phosphorylates
-Condensin
-Cohesin
-pore proteins, INM proteins, Lamins, chromatin, histones
-MAPs
-APC
23
Q

M cyclin cdk

A 
Activated by cdc25
Phosphorylates
-Condensin
-Cohesin
-pore proteins, INM proteins, Lamins, chromatin, histones
-MAPs
-APC

Bio300 (3 decks)

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