Cellular Regulation Flashcards
1
Q
Adaptive Immunity
A
- Uses antigen antibody interactions to neutralize, eliminate or destroy foreign proteins.
- 7 steps
2
Q
Autoimmunde Disorders affect …
A
- Brain, Bones, Muscles, Skin, Lungs, Nerves, GI, Blood, Thyroid
3
Q
Triggers for Autoimmunde Disorders
A
- Stress
- Hormones
- Metals
- Food antigens
- Pesticides and poisons
4
Q
Lupus Erythematosus
A
- Periods of exacerbations and remissions. Lupus can be difficult to diagnose because of the vague presentation and early manifestation.
- Discoid / Systemic
- Systemic: Affects CT of multiple organs and can lead to organ failure
5
Q
Drugs for SLE
A
- NSAIDS
- Corticocosteroids: More potent than NSAIDS, long term and more side effects ( Cushings ) = Prednisone
- Antimalarial: Decreases absorption of UV light ( Loss of centeral vision )
- DMARDS : Long term
- Monoclonal Antibodies
- Janus Kinase Inhibitors: Blocks the stimulation of the production of proinflammatory cytokines
6
Q
Discharge for SLE
A
- Pneumonia and annual influenza vaccines are recommended
- Both physical and emotional stress can exacerbate SLE
- Sunlight is known to worsen the rash of SLE
7
Q
AChE inhibotors
A
- Increase amount of acetlycholine avaibale to active receptors : Enhances cholinergic action
- Do not bind directly
- Lack sensitivity
- Reversible: Moderate duration
- Irreversible: Long duration
8
Q
Reversible Cholinsterase Inhibitors
( Neostigmine )
A
- Drug of choice for MG
- Cannot readily cross membranes
- Minimal effects on brain and fetus
- Poor substrate
- MOA: Break down acetlycholine into choline and acetic acid
- Split is slower allowing for more AcH
9
Q
Neostigmine
A
- Make more ACH available
- Brady, bronchial constriction, urinary urgency, increased glandular secretions, increased tone and motility in GI, miosis, increases force of contraction in SM
- Toxic levels: Decrease force of contraction in muscle ( Crisis )
