cellular pathology Flashcards

1
Q

pathology

A

the study of disease

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2
Q

disease

A

deviation from normal state of health and wellness

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3
Q

Etiology

A

the cause of the disease

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4
Q

Pathophysiology

A

what happens in the body during disease

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5
Q

pathogenesis

A

both etiology and pathogenesis combined

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6
Q

prevalence

A

how many of the cases are present in a population at risk

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7
Q

Incidence

A

how many cases occur in a population at risk over a given time

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8
Q

symptom

A

subjective reporting by pt

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9
Q

sign

A

observations by health care provider

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10
Q

diagnosis

A

a definition of an illness

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11
Q

treatment

A

intervention that eliminates the disease

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12
Q

Prognosis

A

how well we can predict how a disease is going to act

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13
Q

morbidity

A

incidence or disease state of individual or incidence of illness in a population

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14
Q

mortality

A

incidence of death in a population

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15
Q

Idiopathic

A

cause is unknown

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16
Q

Iatrogenic

A

disease caused by medical intervention

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17
Q

acute

A
  1. sudden and obvious onset

2. short term, develops quickly, resolves quickly

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18
Q

Insidious

A

slow and less obvious

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19
Q

Subacute

A

mid way between acute and chronic

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20
Q

Chronic

A

long term illness that may never resolve, usually sets in slowly

21
Q

Latent

A

no clinical signs evident (incubation period in infectious diseases)

22
Q

Prodromal stage

A

illness is evident but isn’t possible to accurately define it

23
Q

Syndrome

A

a collection of signs and symptoms that occur together in response to illness

24
Q

Atrophy

A

cells decrease in size

25
Q

Hypertrophy

A

cells increase in size

26
Q

Hyperplasia

A

cells increase in number

27
Q

Neoplasia

A

increased growth of tissue (increase in number of cells resulting in a tumour)

28
Q

Metaplasia

A

one mature cell type is replaced by another

29
Q

Dysplasia

A

cells become abnormal in size and shape (precursor to cancer)

30
Q

Anaplasia

A

cells become less differentiated (look like stem cells)

31
Q

Apoptosis

A

programmed cell death

32
Q

Necrosis

A

death of a cell due to metabolic damage

33
Q

Hypoxia

A

lack of oxygen

34
Q

Ischemia (anoxia)

A

lack of blood flow

35
Q

Physical agents

A

heat, cold, radiation

36
Q

mechanical stresses

A

trauma

37
Q

Coagulative necrosis

A

most common, cell proteins are altered, prevention of lysis, typically in solid internal organs
mostly occurs from anoxia(ischemia)

38
Q

Liquefactive necrosis

A

dead cells liquefy, most often in brain, can be second stage to coagulative necrosis

39
Q

Caseous necrosis

A

typically in tuberculosis (fungal infections), special coagulative necrosis with limited liquefaction, tissue becomes cheesy and yellow/white

40
Q

Fat necrosis

A

special liquefactive necrosis, limited to fat tissue (pancreas or breast)

41
Q

PMNs

A

most numerous of circulating WBC, up to 5 nuclei, 1st cell to arrive at inflammation cite

42
Q

Eosinophils

A

2-3% of circulating WBC, slower mobility and reaction to stimuli, Segmented nucleus (2), allergic reactions and parasites

43
Q

Basophils

A

less than 1% of circulating WBC, important for inflammation, mediated by IgE, larger than PMNs

44
Q

Macrophages

A

deerived from blood monocytes, larger than PMNs, 3-4 days after onset of inflammation

45
Q

Platelets

A

no nucleus, released from megakaryocytes in the bone marrow, contain granules

46
Q

Lymphocytes

A

involved in chronic forms of inflammation

47
Q

transudate

A

fluid that passes through the membrane, fewer cells than exudate

48
Q

Exudate

A

fluid released from body with high concentration of cells and protein

49
Q

PAthogenesis of inflammation (4)

A
  1. changes in circulation of blood
  2. changes in vessel wall permeability
  3. release of soluble mediators of inflammation
  4. cellular events