Cellular Neurophysiology (long answers) Flashcards
1
Q
What increases the speed of induction?
A
2
Q
Chemical synapse timing event
A
3
Q
synaptic modulation
A
4
Q
receptor tyrosine kinase
A
- a receptor which is associated with the tyrosine part of the protein which means that it can phosphorylate itself (not a GPCR’s)
- process occurs in the membrane
- a docking protein bangs into a secondary messenger and if activated then the receptor will phosphorylates the protein and then the multiple steps occur and trigger cells response
5
Q
Enzyme linked recptors
A
- inactive catalytic domain, they are inactive until a signaling molecule comes along which this signal binds this two and causes a confirmational change in the protein
or - signal molecule turns on an enzyme
6
Q
Enzyme linked receptor: tyrosine kinase-associated receptors
A
- budget version of tyrosine kinase
- we have a receptor via plug in, and a kinase which is not part of the protein
- JAk kinase: associated with receptors that is bound in membrane
- this kinase phosphorylates and turns on proteins, these proteins then leaves and releases cell responses
7
Q
Regulated Intramembrane proteolysis
A
- regulated by a chemical messenger of some form, it’s intramembrane which means int expands the membrane
- activated by proteolysis (breakdown of protein - causes the activation of particular receptor)
- sitting along the membrane then signaling molecule comes along, intracellular part then floats off freely (in cytosol)
- then we get translocation in the nucleus (turning on cell responses)
8
Q
Eicosanoid receptors
A
- localised receptors based on what triggers them
- they mediate our allergic responses, or inflammatory responses, important for blood clotting and other vascular action, important for maturation of foetuses and BIRTH (major role)
- similar to g protein Q (turns on phospholipase C) but different, this turns on phospholipase A which turns on phospholipids (stuff membrane is made of) and takes them to turn into arachidonic acid 9protmotes repair and growth of skeletal muscle tissue)