Cellular Neurophysiology (long answers) Flashcards

1
Q

What increases the speed of induction?

A
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2
Q

Chemical synapse timing event

A
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3
Q

synaptic modulation

A
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4
Q

receptor tyrosine kinase

A
  • a receptor which is associated with the tyrosine part of the protein which means that it can phosphorylate itself (not a GPCR’s)
  • process occurs in the membrane
  • a docking protein bangs into a secondary messenger and if activated then the receptor will phosphorylates the protein and then the multiple steps occur and trigger cells response
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5
Q

Enzyme linked recptors

A
  • inactive catalytic domain, they are inactive until a signaling molecule comes along which this signal binds this two and causes a confirmational change in the protein
    or
  • signal molecule turns on an enzyme
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6
Q

Enzyme linked receptor: tyrosine kinase-associated receptors

A
  • budget version of tyrosine kinase
  • we have a receptor via plug in, and a kinase which is not part of the protein
  • JAk kinase: associated with receptors that is bound in membrane
  • this kinase phosphorylates and turns on proteins, these proteins then leaves and releases cell responses
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7
Q

Regulated Intramembrane proteolysis

A
  • regulated by a chemical messenger of some form, it’s intramembrane which means int expands the membrane
  • activated by proteolysis (breakdown of protein - causes the activation of particular receptor)
  • sitting along the membrane then signaling molecule comes along, intracellular part then floats off freely (in cytosol)
  • then we get translocation in the nucleus (turning on cell responses)
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8
Q

Eicosanoid receptors

A
  • localised receptors based on what triggers them
  • they mediate our allergic responses, or inflammatory responses, important for blood clotting and other vascular action, important for maturation of foetuses and BIRTH (major role)
  • similar to g protein Q (turns on phospholipase C) but different, this turns on phospholipase A which turns on phospholipids (stuff membrane is made of) and takes them to turn into arachidonic acid 9protmotes repair and growth of skeletal muscle tissue)
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