Leading causes of death in the world
Cancer
Enumerate the 3 schema of cancer development
Initiation
Promotion
Progression
schema of cancer development: Initiation
carcinogens bind and cause mutation to target cell resulting to the dysfunction in differentiation and proliferation
schema of cancer development: Promotion
initiated cells are stimulated by promoters which results in these cells on becoming cancerous
schema of cancer development: Progression
stimulates angiogenesis which makes this cancer cell to infect adjacent tissue and travel to other areas, or metastasis
Primary detection and prevention (4)
Secondary detection and prevention
Tertiary detection and prevention (2)
- screening for the development of second malignancies (leukemia, lymphoma)
Family history assessment (3)
signs and symptoms of cancer (9)
CAUTION US C - change in bowel or bladder habits A - a sore that does not heal U - unusual bleeding or discharge T - thickening or lump in the breast I - indigestion or difficulty swallowing O - obvious change in wart or mole N - nagging cough or hoarseness
U - unexplained anemia
S - sudden weight loss (5kg or more)
S&S Bladder , Kidney
Blood in urine; pain and burning with urination; increased frequency or urination
S&S Breast
Lump (s), thickening, physical changes in the breast; itching, redness, nipple
soreness not associated with breast-feeding or menstruation
S&S Cervical and
Uterine
Bleeding between menstrual periods; unusual discharge; painful menstrual
periods; heavy periods
S&S Colon
Rectal bleeding; bloody stool; changes in bowel habits constipation
S&S Endometrial
Same signs as for cervical and uterine cancers above
S&S Laryngeal
Persistent cough; hoarse throat
S&S Leukemia
Paleness; fatigue; weight loss; repeated infections; easy bruising; bone and joint pain; nosebleeds
S&S Lung
A persistent cough, sputum with blood; heavy chest and or chest pain
S&S Lymphoma
Enlarged, rubbery lymph nodes; itchy; night sweats; unexplained fever, weight loss
S&S Mouth and
Throat
A chronic ulcer of the mouth, tongue, or throat that does not heal
S&S Ovarian
Often no obvious symptoms until it is in later stages of development
S&S Prostate
Weak ,interrupted urine flow; continuous pain in lower back, pelvis, upper thighs
S&S Skin
Tumor or lump under the skin, resembling a wart of an ulceration that never heals; moles that change color or size, flat sores; lesions that look like moles
S&S Stomach
Indigestion and pain after eating; weight loss; blood in vomit