Cells Under and their diseases

Question 1

Howell-Jolley Bodies

Answer 1

Coeliac disease

Question 2

Schistocytes

Answer 2

(fragmented or broken RBC’s)
Seen in Haemolysis

Question 3

Teardrop cells

Answer 3

Teardrop shaped RBC’s are seen in Myelofibrosis

Question 4

Reed Sternberg cells

Answer 4

Giant multi-nucleated cells derived from B lymphocytes.
Seen in Hodgkin’s Lymphoma

Question 5

Heinz bodies

Answer 5

large Inclusion bodies within their RBC’s Composed of denatured Haemoglobin.
Seen in G6PD deficiency.

Question 6

Auer Rods

Answer 6

Auer rods are needle-shaped structures which are present in the cytoplasm and contain peroxidase.

Acute Myeloid Lukaemia

Question 7

Rouleaux formation

Answer 7

clumped red blood cells. It is usually the result of abnormally high levels of proteins such as immunoglobulins in multiple myeloma.

Question 8

Philedelphia Chromosome

Answer 8

The Philadelphia chromosome (BCR-ABL fusion gene) is found in most patients with chronic myeloid leukaemia (CML) and occasionally in patients with AML

Question 9

Target Cells

Answer 9

This altered membrane morphology is typically caused by changes in the ratio of surface area to volume of the red blood cell (RBC), leading to the formation of the central darker area surrounded by a lighter ring.

1. Liver disease, especially obstructive jaundice
2. Iron deficiency anaemia
3. Thalassaemia

Question 10

Ringed Sideroblasts

Answer 10

These are erythroblasts containing iron-laden mitochondria.
In the bone marrow

Sideroblastic Anaemia

Question 11

What are Akanthocytes?

Answer 11

These cells have irregularly spaced, thorn-like projections on their surface, giving them a spiky or “spur cell” appearance when viewed under a microscope
- can occur in alcohol induced Non-megaloblastic Macrocytic anaemia.

Question 12

starry sky

Answer 12

Burkitt lymphoma is a high-grade aggressive Non-Hodgkin’s lymphoma.
STARRY SKY IS PATHONEUMONIC

Question 13

H.Pylori

Question 14

Tumor Lysis syndrome