Cells and Organs of the Immune System

Question 1

What are the two types of lymphoid organs?

Answer 1

Primary and Secondary

Question 2

What organs are involved in the primary immune system?

Answer 2

Thymus and bone marrow

Question 3

What organs are involved in the secondary immune system?

Answer 3

Spleen, lymph nodes, tonsil, lymphatic ducts, GALT; Peyer’s patches

Question 4

Where are lymphocytes generated and undergo development and maturation?

Answer 4

In the primary lymphoid organs

Question 5

Where do mature lymphocytes interact with antigens?

Answer 5

Secondary lymphoid organs

Question 6

Does plasma have cells?

Answer 6

No

Question 7

New immune cells are generated by _____ in the bone marrow

Answer 7

Hematopoiesis

Question 8

Stem cells: (2 things)

Answer 8

1. are self-renewing
2. can differentiate into diverse cell types

Question 9

What cells are involved in the innate immune system?

Answer 9

Eosinophils
Basophils
Neutrophils
Mast Cells
Natural Killer Cells

Question 10

What cells are involved in the bridge of innate and adaptive immune systems?

Answer 10

-Monocyte
-Macrophage
-Dendritic Cell

Question 11

What cells are involved in the adaptive immune system?

Answer 11

T lymphocyte
B lymphocyte
NKT cells

Question 12

The myeloid lineage develops from ___

Answer 12

a common myeloid progenitor

Question 13

The myeloid lineage includes:

Answer 13

the first responders and megakaryocyte cells that make platelets and red blood cells

Question 14

What cells are granulocytes?

Answer 14

Neutrophils, Eosinophils, Basophils and Mast Cells

Question 15

What cells are phagocytes, PMN leukocytes, first to the site of infection, migrate from blood to tissue

Answer 15

Neutrophils

Question 16

What cells are phagocytes and are migrating cell types

Answer 16

Eosinophils

Question 17

What cells are NOT-phagocytic, release substances from granules, and play a major role in allergy

Answer 17

Basophils

Question 18

What cells are found in tissues, contain cytoplasmic granules, and play a major role in allergy

Answer 18

Mast Cells

Question 19

Granulocytes are stained with:

Answer 19

hematoxylin and eosin (H&E)

Question 20

Is basic/positive so stains acidic structures blue i.e nucleic acids

Answer 20

Hematoxylin

Question 21

Is acidic/negative so stains basic structures pink, i.e granules in basophils

Answer 21

Eosin

Question 22

What cells are professional antigen-presenting cells (pAPC)

Answer 22

Macrophages, B cell, and dendritic cells

Question 23

Are both myeloid and lymphoid origins, specialized for antigen presentation to T cells, and immature __ are phagocytic

Answer 23

Dendritic Cells

Question 24

What is different about follicular dendritic cells?

Answer 24

They are a different lineage
-found in lymph nodes
-bind Ab:Ag complexes
-important for B cell activation and maturation

Question 25

What cells are involved in the lymphoid lineage?

Answer 25

B lymphocyte
T lymphocyte
Innate lymphoid cells: NKC, ILC1, ILC2, ILC3, LTi
Lymphoid-derived dendritic cells

Question 26

Produce antibodies and act as pAPC

Answer 26

B lymphocytes

Question 27

Interact with other immune cells (APCs) or target cells

Answer 27

T lymphocytes

Question 28

Directly kill tumour cells and virally-infected cells

Answer 28

Natural killer cells

Question 29

What are the two major types of T cells?

Answer 29

T helper cells and cytotoxic T cells
Both recognize Ag presented by MHC via their TCR but co-receptors regulate the APC that they interact with

Question 30

What cell interacts with type 1 MHC?

Answer 30

CD8 + T cell

Question 31

What cell interacts with type 2 MHC?

Answer 31

CD4 + T cell