Cells and Chromosomes Flashcards
Matthias Schleiden and Theodore Schwann
Plants and animals are composed of cells
Rudolf Virchow
every cell comes from a cell
Three basics ideas
- All living organisms are made up of cells
- Cells are the basic building blocks of life
- All cells come from existing cells
Nucleus Makeup
3.65 pg of DNA
3 billion base pairs
20,000 protein genes (haploid cells)
What do mitochondria have?
their own DNA
Nucleus contains
nucleolus, chromatin, nuclear DNA, and chromosomes
Nucleolus function
Ribosomal RNA synthesis
Chromatin makeup
DNA+proteins
Chromosomes makeup
composed of chromatin, contain all genetic information, divide DNA equally
Who created the Chromosomal Theory of Inheritance?
Walter Sutton and Theodore Boveri
Chromosomal Theory of Inheritance
- chromosomes are carriers of units of inheritance- genes
2. chromosomes maintain genetic continuity through generations
Centromere
important for the division of cells; every chromosome has one
Metacentric
centromere located in the middle of the chromosomes
Submetacentric
centromere located between the middle and the end of a chromosome
Acrocentric
centromere located close to the end of the chromosome
Where are the telomere/how many are there per chromosome?
the end of each chromosome arm/there are 4
How to identify the p vs q arm of a chromosome
p arm is the short arm
q arm is the long arm
Diploid number
same size/morphology
same genes
same or different alleles
Haploid number
one homolog from father and another from mother
each has 2 chromatids
homologs have 4 chromatids
What is cytology?
Science of cells
What is cytogenetics?
Science of chromosomes
What is the human diploid number?
2n=46
What is the human haploid number?
1n=23
Karyotype
complete set of chromosomes in a cell of an organism
What is Haldane’s rule?
- mammalian interspecific hybrids: males are usually sterile, rare, or absent
- Female hybrids might be fertile
Molecular causes of hybrid sterility
cytogenetic (in meiosis phase)
molecular (in DNA sequencing)
Epigenetic (in gene regulation)