Cell Structure Flashcards
M phase
chromosomes condense, nucleus & cytoplasm divide
G1 Phase (gap)
interval between end of mitosis and beginning of S
S Phase (synthesis)
nuclear DNA replicated
G2 Phase
interval between end of S phase and beginning of mitosis
Interphase
G1+S+G2
G0
quiescence; cease dividing. then enter into S phase
How often does cell cycle happen?
every 12 hours in intestinal epithelial cell, once a year in liver cell, some cells exit cell cycle.
phases of mitosis
prophase, prometaphase, metaphase, anaphase, telophase, cytokenesis
prophase
chromosomes condense, not attached to mitotic spindle
prometaphase
nuclear envelope disassembled, mitotic spindle sends out microtubules, microtubules bind to kinetochore at centromeres and capture chromosomes
metaphase
chromosomes align along equitorial plate
anaphase
sister chromatid connections cut, one of each travel to opposite poles
telophase
nuclear envelope reassembles to form 2 daughter nuclei, chromos decondense into interphase state
G2/M Checkpoint
unreplicated DNA prevent entry to M phase (mitosis)
Spindle Checkpoint (aka Metaphase Checkpoint)
improper assembly of spindle leads to arrest in anaphase (chromosomes not lined up)