Cell Signalling I Flashcards

1
Q

What are the types of cell signalling that can take place?

A

Contact-dependent

Juxtacrine

Paracrine

Synaptic

Endocrine

Autocrine

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2
Q

What is contact-dependent signalling?

A

Signalling that requires direct membrane-membrane contact. Also known as juxtacrine signalling

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3
Q

How are hormones classified by chemical properties?

A

Solubility and size. Split into 3 major groups:

Small lipophilic (eg corticoids and oestrogen)

Hydrophilic (eg polypeptides such as insulin)

Large lipophilic (eg prostaglandins)

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4
Q

Define 7 steps for essential and specific information transfer:

A

Synthesis of hormone

Release

Transport (to target cell)

Detection (binding to receptor)

Transduction (moves signal from outside to inside the cell)

Target cell response

Termination of signal

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5
Q

What responses can target cells have?

A

Changes in enzyme activity (very fast)

Changes in protein expression (Relatively slower with longer lasting effects)

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6
Q

Can cells have different responses to the same hormone?

A

Yes, they can respond to the same stimulus but invoke a different biological response

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7
Q

Can hormones cause more than one change in a cell?

A

Yes

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