Cell signalling Flashcards
What is cell signalling?
Communication between cells.
What are the 4 different ways of cells communicating?
- Contact dependent
- Paracrine
- Endocrine
- Neuronal
Contact dependent signalling
Touching. Membrane bound signal molecule.
Paracrine signalling
Secrete things within local vacinity
Endocrine signalling
Homones secreated by one tissue or groups of cells. Signal see by every cell in the body.
Neuronal signalling is not Cell signalling!
Constantly firing with electrical and chemical signalling.
What is wnt?
Secreated protein. Idea was in a paracrine fashion.
Transport proteins
Latch onto another protein.
Exovesicles
From vesicles to move into another cell
Cytoneme
Send finger like processors and give the protein to cell.
Post translational modifications
Phosphorylation. Anything that happens to the protein after translation has taken place.
Phosphorilation
Addition of a phosphate group to 3/20 particular amino acids:
Threonine
Serine
Tyrosine
By a Kinase - movement of Phosphase from ATP to a protein.
De-phosphorilation
Phosphetase - Take phosphate off.