Cell Pathology Principles

Question 1

What is lipidosis and where does it occur

Answer 1

IC accumulation of lipid in response to insilts, hypoxia, etc (in liver, muscle and kidney) liver esp succeptible as has a key role in lipid metabolism

Question 2

Key mechanisms of hepatic lipidosis

Answer 2

Excessive FFAs into liver (diet or adipose breakdown) excessive uptake from blood in -ve E balance situation
Toxic damage affecting FA and TG metabolism

Question 3

Hydropic degen pathogenesis

Answer 3

Often due to hypoxia
Reduced ATP level
Anaerobic met
Decr glycogen and incr lactate and Pi (some cells can’t switch to anaerobic so more prone to hypoxic damage eg neurons)
Inhib of mem Na/K pumps so H2O move into cell

Question 4

Hydropic degen morphology

Answer 4

Vacuolated cytoplasm of cells (v large - ballooning degen)

Reversible if stimuli removed

Question 5

Areas esp succeptible to hydropic degen

Answer 5

Hepatocytes
Prox renal tubular epi
Cardiac myocytes
Endothelial cells

Question 6

Oncotic necrosis conditions

Answer 6

Often assoc with incr Ca2+ level IC

Question 7

Necrotic cell staining

Answer 7

Cytoplasm more pink/eosinophillic