Cell migration Flashcards
Neme of ducts that join at the subclaian vein?
thoracic ducts.
What is the common mucosoula system?
That some lymphoctyes from MALTs can also home to other MALts, preferential and not specific.
What do T cells and HEVs express for tethering? chemokine adhesion, and rolling/ arrest?
T cells will express L-selctin which can bnid to sialyl x luis e.g. GlyCam on the endothelial cells.
HPS bound chomkines like CCL19/21 can bind to T cell CCR7. (Can activate the integrins LFA-1).
LFA-1 binds to ICAM-1/2 for rolling and arrest.
What do neutrophils cells and endothelial cells express for tethering?
Opposite than T cells, Neutrophils express the sialyl X luis and bind to P and E selection on the endothelial cells.
What environment is rich in sphingosine 1 phosphate?
the efferent lymph is rich in S1P (and medullary sinus). When drawn into lymph node, T cells have downregulated S1Preceptors.
How do T cells move out of lymph nodes? What makes them stay in longer after activation?
They upregulate S1P and downregulate CCR7.
TCR activation will keep S1P downregulated longer.
What changes increase the effectiveness of T cells in LN?
Increase in the CCR5 move towards local CCL3,4 production (CD8+?)
Or upregulates CXCR3 on CD4 to got to CCL10 medullary zones.
What do gut DCs produce for homing?
RA. Induces CCR9 expression on T cells.
What homing signals induced for skin-homing T cells?
UPregulates CCR4 and CCR10 and P and E selectin.
Which walk is more efficient? Brownian or lewy walk?
Lewy walk!
