Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

BMS > Cell Junctions > Flashcards

Cell Junctions Flashcards

1
Q

Selectins-structure and function

A

Transmembrane proteins that bind oligosaccharides (CAD domain) and Ca2+, important in Homing process

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Tight Junction 2 Functions

A

Pore, Barrier

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Focal Adhesions-mediated by

A

Integrins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Belt Desmosomes (Zona Adherens)-mediated by

A

Cadherins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Claudins-Function

A

Regulate paracellular permeability of ions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Hemidesmisomes-location and function

A

Found on basal surface (mediate interaction of cells and basement membrane)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Spot Desmosomes (macula Adherens)-mediated by

A

Desmoglein, Desmocollins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Belt Desmosomes–Cadherin adhesion molecule—cytoskeleton

A

Cadherin: transmembrane adhesion molecules that mediate adhesion in the belt Desmosome
Cadherins are attached to the actin cytoskeleton via Catenins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Spot Desmosomes-structure/function

A 
Dense plaques (Desmoplakin, plakoglobin) with Int. Fils (keratin) coming off 
-cell-cell junctions
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Integrins-interaction with ECM proteins

A

Via RGD peptide sequences

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Connexons-structure and function

A

Made of 6 Connexin proteins, link up to other cell Connexon to create hydrophilic channel for ions to pass through (cell-cell communication)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Blistering Diseases (2)

A
  1. Pemphigus Foliceas

2. Bulbous Pemphigoid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Focal Adhesions, function and visualization

A

help with cell migration, visualized best via immuno-EM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Hemidesmisomes (mediated by)

A

Integrin a6B4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Spot Desmosomes- cytoskeleton

A

Intermediate filaments

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Gap Junctions-formed by

A

Connexons

17
Q

Cadherins: 1. Which junction? 2. Depends on? 3. Two Examples and their related diseases

A
  1. Belt Desmosomes
  2. Need calcium to function
  3. E-Cadherin: cell-cell adhesion in epithelia (loss=Epithelial Mesencyhmal Transition, EMT, in cancer progression)
    P-Cadherin: Select tissues (hair, retina) show issues if mutated
18
Q

Two key IgCAMs (homing)

A

ICAM and VCAM

19
Q

Tight Junctions-cytoskeleton

A

Actin via adaptor proteins (ZO-1)

20
Q

ClaudinS 16/19

A

Regulate kidney perm to Ca and Mg (dysfunction-misreuptake of those ions)

21
Q

Integrins- location and structure

A 
Transmembrane proteins that bind to ECM proteins and Cytoskeleton 
Two subunits (a and B)
22
Q

IgCAMs- structure and function

A

EC domain-Ig-like, Ca+ independent, are adhesion molecules

23
Q

Integrins- interaction with cytoskeleton

A

Interact with actin-linked cell matrix adhesions sites (focal adhesions)

24
Q

Leukocyte Extravision Process-What is on the surface of the endothelial cells?

A

Selectins-adhesion to slow down Leukocytes at first

ICAM, VCAM-to bind to Integrins on Leukocytes to arrest their movement

25
Q

Hemidesmisomes-cytoskeleton

A

Interact via intermediate filaments

26
Q

Focal Adhesions-cytoskeleton

A

Linked to actin filaments of cytoskeleton

27
Q

Leukocytes Extravision Process- What are on the Leukocytes?

A

Integrins

28
Q

Bullous Pemphigoid

A

Caused by mutation that impacts hemidesmisome adhering molecules
Blisters form between basal layer of epithelia and basement membrane

29
Q

Leukocyte Extravision Process

A
  1. Leukocytes slow and being to ROLL on endothelial surface due to loose adhesion with Selectins on endothelial surface
  2. Integrins on Leukocytes are activated and bind ICAM and VCAM on endothelial cell surface
  3. Leukocytes are arrested on endothelial cell surface
  4. Integrin-mediated migration of Leukocytes through wall of blood vessels (in between endothelial cells) occurs
30
Q

Tight Junctions- mediators

A

Occludins, Claudins

31
Q

Pemphigus Foliceas

A

Caused by mutation in adhering molecule of Spot Desmosomes (desmigleans)
Blisters in between layers of epithelia

32
Q

Connexon permeability

A

Regulated by many factors (voltage, Ca, pH, etc.)

33
Q

Dynamic Adhesions (2)

A
  1. Selectins

2. IgCAMs

34
Q

Catenins

A

Link Cadherins (belt Desmosomes) to actin cytoskeleton

BMS (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions