Cell Injury & Cell Death Flashcards
Necrosis
Cell death due to injury
-Initiated by pathologic stimuli from outside the cell and results in the dissolution or removal of that cell
Apoptosis
Cell death due to physiological turn over of cells
- Involves activation of a coordinated internal cellular program that are mediated by defined cellular proteins
- A specific, energy dependent, programed cell death
- Helps to maintain homeostasis
Calcium Influx
Hallmark of irreversible cell injury or cell death
Morphologic Characteristics
- excessive cell swelling
- dramatic changes to cellular organelles
Adaptation
Allows cells to survive in the short term
Homeostasis
(LOSS OF) forms the basis of most disease states
Cellular Adaptions
- Hyperplasia
- Hypertrophy
- Metaplasia
- Dysplasia
Atrophy
the shrinkage of tissue or organ size due to a reduction in cell size
Hypertrophy
An increase in cell size in response to stress
Hyperplasia
An increase in cell number and is distinct from hypertrophy
Non-dividing cells
(CARDIAC MYOCYTES) cannot divide, so adapt through hypertrophy
Dividing cells
(EPITHELIAL CELLS) may undergo hyperplasia as well as hypertrophy under stress
Metaplasia
The reversible process whereby one mature cell type is replaced by another less mature cell type
Dysplasia
Disordered growth and maturation of the cellular components of a tissue
Accumulate Substances
Under stress, cells tend to do this in response to metabolic derangments
Hallmarks of cell injury
-Accumulating substances leading to cell injury or cell death
Mechanisms of Cellular injury
Pathologic stimuli
- Intrinsic (genetic) or extrinsic (acquired)
- Provide etiology (cause) of disease
- Elicit cellular responses - pathogenesis of disease
Severity & Duration
(of pathologic stress) determine outcome of cell injury
Causes of Necrosis
- Trauma
- Intoxication
- Deficiency
Mechanisms of Cellular Injury
-Hypoxic Cell Injury: Impaired energy production
-Free Radical Injury: Form damaging reactive oxygen species (ROS)
-Impaired Calcium Homeostasis: Compromise cell membrane
CALCIUM INFLUX=Cell death
Reactive Oxygen Species (ROS)
Protection: superoxide disumtase (SOD) converts superoxide into hydrogen peroxide
-Catalase converts hydrogen peroxide into water and oxygen
Excess ROS
Form when oxygen is limited
- Damage the cell (lipids, proteins, etc.)
- Leaking Membranes
- Calcium Influx
- Cell death
Ischemia
Lack of blood flow (oxygen)
Coagulative Necrosis
- Basic cell outline is preserved
- Acidosis denatures proteins
- Protenin denaturation causes coagulation