cell division and dna replication Flashcards
DNA replication
happens prior to cell division
- 2 identical DNA molecules are produced, they are semi-conservative as they contain one original strand and a new strand.
- 1) DNA double helix unwinds with the aid of helicase
-2) h bonds between n base pairs break (unwind)
-3) NUcleotides from within the nucleus ( Okazaki fragments) assemble opp each strand, using ATP to join them together.
Mitosis
- cell division producing cells needed for growth and repair.
- produces 2 genetically identical daughter cells to their parents’ cells.
- mitosis occurs rapidly during early stages of growth, e.g seedlings, infants, root tips, embryos, zygotes and etc.
- Interphase, PMAT
Cell Cycle
Interphase = G1+S+G2
M=Mitosis
G1= Growth (most growth - high rate of metabolic processes)
S= Synthesis of DNA
G2= Growth
Mutations
Spontaneous and random, they result from chance.
- however, the rate of mutations could be determined by environmental factors and exposure to mutagens.
Block mutations or chromosomal mutations
removal of entire genes or chromosomes
Meiosis
Cell division that occurs in sex organs and produces Sex cells (Gametes).
- gametes produced are haploid. 23
- when they fuse in fertilisations, homologous chromosomes formed, therefore they become diploid 2n. 46
- occurs twice.
Independent assortment
homologus pairs of chromosomes line up random order during metaphase 1 of meiosis.
Segregation
the independent separation of alleles on different chromosomes.
order of variation
Crossing over, INdependent Assortment, Segregation
Crossing over linked genes
parts of non-sister chromatids can cross over at the chiasma. Exchanging segments of DNA, which result in different combinations of alleles. Resultant gametes = recombinants.