Cell death

Question 1

What correlates to the amount of innervation a target receives?

Answer 1

Size of the target = more innervation

Question 2

What therefore might the target be providing?

Answer 2

Trophic support

Question 3

Is the target telling it to make more neurons or is trimming off neurons when a target is reached?

Answer 3

Trimming off

Question 4

What is the neurotrophic factor hypothesis therefore?

Answer 4

1. Neurons are produced in excess and that excess is eliminated over time
2. Neurotrophic factors emanate from targets to promote survival according to tissue size

Question 5

What are the types of antiapoptotic genes?

Answer 5

Pro-apoptotic

Anti-apoptotic

Question 6

What are the 2 classes of caspase?

Answer 6

Initiator caspase (e.g. caspase 9)
Executioner/effector caspase (e.g. caspase 1)

Question 7

What is the difference between tropic and trophic?

Answer 7

Trophic – nourish

Tropic – drive or turn into

Question 8

What happens if the neuronal processes have no NGF?

Answer 8

They retract but they can also guide growth cones in vitro

Question 9

Is NGF tropic or trophic?

Answer 9

BOTH!!!!!

Question 10

What is the high affinity receptor for NGF?

Answer 10

TrkA

- Tyrosine kinase receptor

Question 11

What neurotrophin (NT) supports many neuronal types early in development?

Answer 11

NT3

Question 12

What caspase is activated at NGF deprived sites?

Answer 12

Caspase 6

Question 13

What is caspase 6 activated by?

Answer 13

Amyloid precursor protein (APP) which binds to death receptor 6

Question 14

What family does death receptor 6 belong to?

Answer 14

Tumour necrosis factor (TNF)