Cell damage and cell death

Question 1

What condition/event doesn’t result in necrosis?

Answer 1

Digit formation

Question 2

Streptococcus pneumonia can cause cellular destruction and pus formation. Which type of necrosis is this?

Answer 2

Liquefactive necrosis

Question 3

Cells receive a combination of survival signals and apoptotic signals. In which circumstance will a cell not undergo apoptosis?

Answer 3

Sudden trauma

Question 4

DNA damage can result in p53 activation, which in turn will cause?

Answer 4

Increased transcription - translation of Bax, Bax is then embedded into the outer mitochondrial membrane to form a pore for cytochrome C

Question 5

A major step of the intrinsic pathway is?

Answer 5

Cytochrome C binding to APAF, cleaving procaspase 9

Question 6

Caspases are important in apoptosis, which one of these statements is not true?

Answer 6

They are only activated if cytochrome c is release from the mitochondria

Question 7

MPPT was found to induce parkinson’s disease in prime apes. Using fluorescent microscopy, before induction of MPPT cytochrome c in the cytoplasm was undetected. After induction cytochrome c was localised to the cytoplasm. What sensible deduction can you make?

Answer 7

There was an increase in the mitochondria’s permeability