Cell-cycle specific anticancer drugs Flashcards
Methotrexate side effects?
bone marrow suppression
Methotrexate moa?
S phase specific antimetabolite that inhibits DHF reductase(folate synth)
5-Fluorouracil moa?
inhibit thymidylate synthetase(dUMP - dTMP)
topical anticancer drug used to cure BCC and keratoses?
5-Fluorouracil
6-Mercaptopurine moa?
activated by HGPRT and subsequent purine
6-Mercaptopurine drug interaction?
Allopurinol. Because 6-mercaptopurine is metabolized by Xanthine Oxidase
Bleomycin moa?
complexes with Fe and Oxygen to produce DNA strand breaks
Bleomycin phase specificity?
G2 phase
Bleomycin side effect?
pulmonary fibrosis
Vinblastine and Vincristine moa?
spindle poisons. Inhibit microtubule polymerization
Vinblastine side effect?
bone marrow suppression
Vincristine side effect?
Neurotoxicity
Antimetabolites dose-limiting toxicity?
Bonemarrow suppression
Methotrexate general picture?
- inhibits dihydrofolate reductase
- resistance by gene amplification
- used in severe psoriasis
- myelosuppressive
Procarbazine general picture?
- DNA, RNA and protein synthesis inhibitor
- Weak MAO inhibitor(may cause hypertension)
3 x Selective Estrogen Receptor Modulators?
- Tamoxifen
- Toremifen
- Raloxifen
Moa SERMs?
- inhibit estrogen dependent cellular prolifferation
- increased TGF-B(increased growth-inhibition)
Role of Allopurinol in cancer chemotherapy?
Administered to protect against hyperuricemia and nephrotoxicity after the massive tumor cell lysis that may follow cancer chemotherapy.
Leuprolide area of use?
Used to treat prostate cancer by lowering FSH and LH which subsequently reduces production of testosterone - which the tumor depends upon for growth.
