Cell-cycle specific anticancer drugs

Question 0

Methotrexate side effects?

Answer 0

bone marrow suppression

Question 1

Methotrexate moa?

Answer 1

S phase specific antimetabolite that inhibits DHF reductase(folate synth)

Question 2

5-Fluorouracil moa?

Answer 2

inhibit thymidylate synthetase(dUMP - dTMP)

Question 3

topical anticancer drug used to cure BCC and keratoses?

Answer 3

5-Fluorouracil

Question 4

6-Mercaptopurine moa?

Answer 4

activated by HGPRT and subsequent purine

Question 5

6-Mercaptopurine drug interaction?

Answer 5

Allopurinol. Because 6-mercaptopurine is metabolized by Xanthine Oxidase

Question 6

Bleomycin moa?

Answer 6

complexes with Fe and Oxygen to produce DNA strand breaks

Question 7

Bleomycin phase specificity?

Answer 7

G2 phase

Question 8

Bleomycin side effect?

Answer 8

pulmonary fibrosis

Question 9

Vinblastine and Vincristine moa?

Answer 9

spindle poisons. Inhibit microtubule polymerization

Question 10

Vinblastine side effect?

Answer 10

bone marrow suppression

Question 11

Vincristine side effect?

Answer 11

Neurotoxicity

Question 12

Antimetabolites dose-limiting toxicity?

Answer 12

Bonemarrow suppression

Question 13

Methotrexate general picture?

Answer 13

• inhibits dihydrofolate reductase
• resistance by gene amplification
• used in severe psoriasis
• myelosuppressive

Question 14

Procarbazine general picture?

Answer 14

• DNA, RNA and protein synthesis inhibitor

- Weak MAO inhibitor(may cause hypertension)

Question 15

3 x Selective Estrogen Receptor Modulators?

Answer 15

• Tamoxifen
• Toremifen
• Raloxifen

Question 16

Moa SERMs?

Answer 16

• inhibit estrogen dependent cellular prolifferation

- increased TGF-B(increased growth-inhibition)

Question 17

Role of Allopurinol in cancer chemotherapy?

Answer 17

Administered to protect against hyperuricemia and nephrotoxicity after the massive tumor cell lysis that may follow cancer chemotherapy.

Question 18

Leuprolide area of use?

Answer 18

Used to treat prostate cancer by lowering FSH and LH which subsequently reduces production of testosterone - which the tumor depends upon for growth.