CELL CYCLE AND CANCER Flashcards
IS DRIVEN BY A BUILD IN CLOCK THAT CAN BE ADJUSTED BY EXTERNAL STIMULI.
CELL CYCLE CONTROL SYSTEM
A CRITICAL CONTROL POINT IN THE CELL CYCLE WHERE STOP AND GO AHEAD SIGNALS CAM REGULATE THE CELL CYCLE.
CHECKPOINT
THREE MAJOR CHECKPOINTS ARE FOUND IN..
G1,G2, and M PHASE
RESTRICTION POINT
G1 CHECKPOINT
IF CELL DOES NOT RECEIVE THE GO AHEAD SIGNAL IT WILL EXIT THE CELL CYCLE AND SWITCH TO A NON DIVIDING STATE CALLED [BLANK]
G0
[BLANK] WHICH STIMULATE CELL DIVISION, PRIMARILY BY RELIEVING INTRACELLULAR NEGATIVE CONTROLS.
MITOGENS
Where most cell of the human body
G0
WHAT ARE THE EXTERNAL INFLUENCES
MITOGENS, GROWTH FACTORS, SURVIVAL FACTORS
OTHER FACTORS INFLUENCING GROWTH AND DIVISION.
DENSITY DEPENDENT INHIBITION, ANCHORAGE DEPENDENCE, CELLS WHICH NO LONGER RESPOND TO CELL CYCLE CONTROLS
FOR MOST ANIMAL CELLS TO DIVIDE, THEY MUST BE ATTACHED TO A SUBSTRATUM SUCH AS THE EXTRACELLULAR MATRIX OF THE TISSUE.
ANCHORAGE DEPENDENCE
CELLS GROWN IN CULTURE WILL RAPIDLY DIVIDE UNTIL A SINGLE LAYER OF CELLS IS SPREAD OVER THE AREA OF TGHE PETRI DISH, AFTER WHICH THEY WILL STOP DIVIDING.
DENSITY DEPENDENT INHIBITION
LIFE DECISIONS A CELL MUST MAKE
STASIS, DIFFERENTIATION, MITOSIS, APOPTOSIS, EXTERNAL AND INTERNAL SIGNALS
THIS PROMOTE CELL SURVIVAL BY SUPPRESSING APOPTOSIS.
SURVIVAL FACTORS
PROMOTING THE SYNTHESIS OF PROTEINS AND OTHER MACROMOLECULES AND BY INHIBITING THEIR DEGRADATION.
GROWTH FACTORS
ENSURES THAT DNA REPLICATION IN S PHASE HAS BEEN COMPLETED SUCCESSFULLY.
G2 CHECKPOINT
ENSURES THAT ALL OF THE CHROMOSOMES ARE ATTACHED TO THE MITOTIC SPINDLE BY A KINETOCHORE.
METAPHASE CHECKPOINT
CELL CHECKS FOR ERRORS, AND CELL REPLICATES ITS DNA
S PHASE
GROWTH OF VASCULATURE BY PROCESSES OF SPOUTING AND SPLITTING
ANGIOGENESIS
[BLANK] ARE GENES THAT CONTROL NORMAL CELL GROWTH CODE.
PROTO-ONCOGENES
PROTO-ONCOGENES CONTROL NORMAL GROWTH CODE FOR:
GROWTH FACTOR RECEPTORS, MITOGEN RECEPTORS, GROWTH/DIVISION SIGNAL PATHWAY COMPONENTS, SURVIVAL FACTORS.
CAUSES OF MUTATIONS ARE:
RADIATION, SMOKING, POLLUTANTS, CHEMICALS, VIRUSES.
REMAIN CLUMPED; CAN BE REMOVED
BENIGN TUMORS
BREAK APART (METASTASIZE) AND CAN FORM TUMORS IN OTHER PARTS OF THE BODY.
MALIGNANT
[BLANK] ARE KNOWN TO PROMOTE CANCER.
CARCINOGENS
