Cell Communication Flashcards

1
Q

What does a desmosome do?

A

Join cells

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2
Q

What is the function of a gap junction?

A

Communication

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3
Q

What is a tight junction?

A

A belt around cell, anchor to neighbouring cells
Not attached to cytoskeleton
Stops membrane proteins moving past it

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4
Q

What is attached to the cytoskeleton and what is not?

A

Desmosome is

Tight junction is not

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5
Q

What is the role of a desmosome?

A

Anchor cells together
Cadherins form the links between the plaques in the individual cells
To do with structure

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6
Q

What is the role of a gap junction?

A

Channels/bridges formed from connections, allow small molecules and ions to pass through between cells
Can be chemical or electrical

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7
Q

What is paracrine?

A

Cells nearby communicating, short distance communication

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8
Q

What is an example of a paracrine hormone?

A

Nitric oxide - local vasodilator released from endothelial cells

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9
Q

What is auto-communication?

A

Cell communicating with itself

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10
Q

What is an example of autocommunication?

A

Prostaglandins - inflammatory mediator

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11
Q

What are neural examples of communicators?

A

glutamate - excitatory in CNS
acetyl choline - excites skeletal muscle
noradrenaline - causes vasodilation

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12
Q

What are examples of amino acid derived hormones?

A

Adrenaline and noradrenaline

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13
Q

What are the features of catecholamines?

A

Circulate freely or weakly bound to albumin
Short half life
Bind to GPCR

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14
Q

What are the features of thyroid hormones T3 and T4?

A

Circulate bound to plasma proteins
Long half lives
Transported through membranes and bind to nuclear receptors

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15
Q

What are examples of steroid hormones?

A
Oestrogen
Androgens
Aldosterone
Circulate bound to plasma proteins but easily diffuse through cells
Intracellular
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16
Q

How are peptide hormones formed?

A

Usually carved from prohormones when needed, then secreted by exocytosis
Do not usually bind to plasma proteins
Very different in structure so their effects are mediated by several mechanisms

17
Q

What are examples of peptide hormones?

A

TRH, GnRH, ADH, oxytocin, glucagon, somatostatin, vasoactive intestinal polypeptide

18
Q

What are examples of protein hormones?

A

Insulin, insulin like growth factor, GH, PRL

19
Q

What are examples of glycoprotein hormones?

A

TSH, FSH, LH, hCG