Celecoxib (NSAID)

Question 1

What is the brand name of celecoxib?

Answer 1

Celebrex

Question 2

What celecoxib capsule strengths are available?

Answer 2

50mg, 100mg, 200mg, 400mg

Question 3

What are the FDA approved indications of celecoxib?

Answer 3

For the release of the signs and symptoms of osteoarthritis, rheumatoid arthritis, acute pain, colorectal polyps, ankylosing spondylitis

Question 4

What dose of celecoxib is used for osteoarthritis?

Answer 4

200 mg per day given once a day or 100 mg given twice a day.

Question 5

What dose of celecoxib is used for rheumatoid arthritis?

Answer 5

Start with 400 mg in a single dose, followed by a 200 mg dose if needed. For maintenance use, 200 mg twice a day.

Question 6

What is the dose of celecoxib use for adenomatous colorectal polyps?

Answer 6

In addition to usual medical care give 400 mg twice a day with food.

Question 7

What dose of celecoxib is used for the treatment of anklosing spondylitis?

Answer 7

200mg once or twice daily.

Question 8

What is the mechanism of action of celecoxib?

Answer 8

Celecoxib produces its anti-inflammatory, analgesic, and anti-pyretic affect spine hitting prostaglandin synthesis through inhibition of cyclooxygenase-2.

Question 9

What are the drug interactions of celecoxib?

Answer 9

• May decrease the effectiveness of ACE inhibitors.
• May increase plasma lithium levels.
• Fluconazole increases plasma levels.
• Celecoxib is an inhibitor of cytochrome P450 2C9, therefore use with caution with drugs metabolized via this pathway.
• May increase the effects of warfarin

Question 10

Where are the contraindications to celecoxib?

Answer 10

• Contraindicated in patients have experienced asthma, urticaria, or allergic type reaction after taking sulfonamides, aspirin, or other NSAIDs.
• Contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft surgery.
• NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infraction, and stroke.
• Use with extreme caution in patients with a history of ulcer disease or gastrointestinal bleeding.
• NSAIDs have been involved in rare cases of GI bleeding incidents.
• Abnormalities in liver enzyme tests have occurred during treatment.
• Monitor liver function periodically.
• Avoid use in patients with advanced Rena disease and during nursing.
• Avoid use in the late stages of pregnancy because of the possibility of premature closure of the doctors arteriosus.
• Pregnancy Category C

Question 11

What are the adverse effects of celecoxib?

Answer 11

Adverse effects are similar to the seen with placebo and include diarrhea, dyspepsia, abdominal pain, flatulence, edema, and sinusitis.

Question 12

What should the pharmacist tell the patient when counseling them on the use of celecoxib?

Answer 12

• May be taken without regard to meals
• Promptly report any signs of ulceration and bleeding to physician
• Avoid aspirin or products containing aspirin without first consulting a physician
• If a dose is missed, take it as soon as possible. If it is closer to the time of your next does than the dose you missed, skip the missed dose and return to your dosing schedule.