Ceftriaxone Flashcards
Drug Class of Ceftriaxone
Antibiotic
Presentation of Ceftriaxone
• Vial (powder), 1 g ceftriaxone
Schedule of Ceftriaxone
• S4 (Restricted drugs).
Pharmacology of Ceftriaxone
Ceftriaxone is a third generation cephalosporin antibiotic with a bactericidal action.
Metabolism of Ceftriaxone
Ceftriaxone is excreted as a variety of active and inactive metabolites from the body through urine, bile and faeces.
Indications of Ceftriaxone
• Suspected meningococcal septicaemia
(with a non-blanching petechial AND/OR purpuric rash)
Contraindications of Ceftriaxone
- KSAR or hypersensitivity to cephalosporin drugs
- Known anaphylaxis or severe allergic reaction to penicillin based drugs – (isolated minor drug rash attributed to penicillin does not contraindicate the use of ceftriaxone)
Precautions of Ceftriaxone
• Nil
Side Effects of Ceftriaxone
- Nausea AND/OR vomiting
* Pain at the IM administration site
Routes of Administration for Ceftriaxone
Intramuscular injection (IM)
Intravenous injection (IV)
Intraosseous injection (IO)
Onset Time of Ceftriaxone
Dose/route variable
Duration Time of Ceftriaxone
≈ 1 day
Half Life of Ceftriaxone
5.8 – 8.7 hours
Special Notes of Ceftriaxone
- All cannulae and IV lines must be flushed thoroughly with sodium chloride 0.9% following each medication administration.
- All parenteral medications must be prepared in an aseptic manner. The rubber stopper of all vials must be disinfected with a 3MTM Solu-IVTM swab and allowed to dry prior to piercing.
Adult Dose of Ceftriaxone IM
Suspected meningococcal septicaemia
(with a non-blanching petechial AND/OR purpuric rash)
1g
Syringe preparation:
Reconstitute 1 g of ceftriaxone with 3.6 mL of water for injection
in a 10 mL syringe to achieve a final concentration of 1 g/4 mL (250 mg/mL). Single dose only.
Adult Dose of Ceftriaxone IV
Suspected meningococcal septicaemia
(with a non-blanching petechial AND/OR purpuric rash)
1 g
Slow push over 3 – 5 minutes.
Syringe preparation:
Reconstitute 1 g of ceftriaxone with 9.6 mL of water for injection
in a 10 mL syringe to achieve a final concentration of 1 g/10 mL (100 mg/mL). Single dose only.
Adult Dose of Ceftriaxone IO
Suspected meningococcal septicaemia
(with a non-blanching petechial AND/OR purpuric rash)
1 g
Slow push over 3 – 5 minutes.
Syringe preparation:
Reconstitute 1 g of ceftriaxone with 9.6 mL of water for injection
in a 10 mL syringe to achieve a final concentration of 1 g/10 mL (100 mg/mL). Single dose only.
Paediatric Dose of Ceftriaxone IM
Suspected meningococcal septicaemia
(with a non-blanching petechial AND/OR purpuric rash)
50 mg/kg (rounded up to the nearest 5 kg)
Syringe preparation:
Reconstitute 1 g of ceftriaxone with 3.6 mL of water for injection
in a 10 mL syringe to achieve a final concentration of 1 g/4 mL (250 mg/mL).
Paediatric Dose of Ceftriaxone IV
Suspected meningococcal septicaemia
(with a non-blanching petechial AND/OR purpuric rash)
50 mg/kg (rounded up to the nearest 5 kg)
Slow push over 3–5 minutes.
Syringe preparation:
Reconstitute 1 g of
ceftriaxone with 9.6 mL of water for injection
in a 10 mL syringe to achieve a final concentration of 1 g/10 mL (100 mg/mL).
Paediatric Dose of Ceftriaxone IO
Suspected meningococcal septicaemia
(with a non-blanching petechial AND/OR purpuric rash)
50 mg/kg (rounded up to the nearest 5 kg)
Slow push over 3–5 minutes.
Syringe preparation:
Reconstitute 1 g of
ceftriaxone with 9.6 mL of water for injection
in a 10 mL syringe to achieve a final concentration of 1 g/10 mL (100 mg/mL).
