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immunology > CDs and Cytokines > Flashcards

CDs and Cytokines Flashcards

1
Q

What are the Main Cells that Express
And what is the function of

CD3?

A

all T cells

associates with the TCR and mediates TCR signalling

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2
Q

What are the Main Cells that Express
And what is the function of

CD4?

A 
T helper cells, MHC class II reactive T cells; monocytes, macrophages 
binds to MHC class II and helps in signalling for MHC II reactive T cells; binds to HIV
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3
Q

What are the Main Cells that Express
And what is the function of

CD8?

A 
CTLs, MHC class I reactive T cells 
binds to MHC class I and helps in signalling for MHC I reactive T cells
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4
Q

What are the Main Cells that Express
And what is the function of

CD28?

A

T cells

Costimulatory molecule for T cell activation. Binds to CD80 and CD86

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5
Q

What are the Main Cells that Express
And what is the function of

CD40?

A

B cells, macrophages, DCs

Binds to CD154; involved in activation of B cells, DCs, and macrophages

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6
Q

What are the Main Cells that Express
And what is the function of

CD80 aka b7 and b7-1?

A

B cells, macrophages, DCs

Binds to CD28 and CTLA-4. Costimulator for T cell activation.

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7
Q

What are the Main Cells that Express
And what is the function of

CD86 aka b7-2?

A

B cells, macrophages, DCs

Binds to CD28 and CTLA-4. Costimulator for T cell activation.

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8
Q

What are the Main Cells that Express
And what is the function of

CD95 aka Fas, APO-1?

A

Activated T and B cells, monocytes

Induces apoptosis upon interaction with CD178

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9
Q

What are the Main Cells that Express
And what is the function of

CD154 aka CD40 ligand and CD40L?

A

Activated CD4+ T cells

Binds to CD40. Activates B cells, DCs, and macrophages

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10
Q

What are the Main Cells that Express
And what is the function of

CD178 aka Fas-ligand?

A

Induced on T cells and NK cells

Binds to Fas and induces apoptosis on Fas+ cells; important for regulation of the immune response.

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13
Q 
IL-1
What are the Main Cell Source?
Other Cell Sources?
Principal Targets?
Principal Effects?
What are the effects on...
Lymphocytes?
Macrophages?
Endothelium?
Acute phase proteins?
A

main source: macrophages, B cells,NK cells
Second source: endothelium, fibroblasts, astrocytes, etc…
Targets: T cells, B cells, macrophages, endothelium
lymphocyte activation, macrophage stimulation, incr. leukocyte - endothelium adhesion; acute phase proteins, fever

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14
Q 
IL-2
What are the Main Cell Source?
Principal Targets?
Principal Effects?
What is the effect on...
T cells?
NK cells?
A

Main source: T cells
Cell Targets: T cells, NK cells
T cell and NK cell activation and proliferation

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15
Q 
IL-4
What are the Main Cell Source?
Principal Targets?
Principal Effects?
What is the effect on...
B cells?
Th2 cells?
Th1 cells?
A

T cells, Th2 cells, mast cells
B cells, T cells
B cell growth factor, isotype switching to IgE, Th2 cell differentiation; suppress Th1 cells

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16
Q 
IL-5
What are the Main Cell Source?
Principal Targets?
Principal Effects?
What are the effects on...
B cells?
Eosinophils?
A

T cells, mast cells, Th2 cells
B cells
B cell growth factor, isotype switching to IgA; eosinophil growth

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17
Q 
IL-6
What are the Main Cell Source?
Other Cell Sources?
Principal Targets?
Principal Effects?
What are the effects on...
Acute phase response?
Th17?
B cells?
A

Main source: T, B, macrophages
Other sources: endothelium, fibroblasts, astrocytes, stromal cells etc…
Main targets: T, B, macrophages
Induces acute phase response; regulates Th17 differentiation, and proliferation of antibody producing cells

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18
Q

IL-10

What are the Main Cell Source?
Principal Targets?
Principal Effects?
What are the effects on...
Th1 cells?
Macrophage cells?
A

T cells, Th2 cells
Th1 cells
inhibition of cytokine synthesis and macrophage function

19
Q

IL-12

What are the Main Cell Source?
Principal Targets?
Principal Effects?
What are the effects on...
Th1 cells?
NK cells?
A

monocytes, APCs
Th1 cells, NK cells
differentiation of Th1 cells; activation of NK cells

20
Q

TNF-alpha

What are the Main Cell Source?
Principal Targets?
Principal Effects?
What are the effects on...
inflammation?
endothelial cells?
acute phase proteins?
NK cells?
A

Main source: lymphocytes, macrophages, mast cells
Target cells: many cells
proinflammatory; endothelial activation, shock, acute phase proteins, PMN activation

21
Q

TNF-beta

What are the Main Cell Source?
Other Cell Sources?
Principal Targets?
Principal Effects?
What are the effects on...
inflammation?
B cells
A

main source: T cells, monocytes
Other sources: most cells
Targets: most cells
inhibits cell activation, anti-inflammatory, promotes IgA secretion

22
Q

Interferon-alpha/Beta

What are the Main Cell Source?
Other Cell Sources?
Principal Targets?
Principal Effects?

A

most cells
most cells
most cells
antiviral; increased MHC class I expression

22
Q

CD 62L

What is the cell this CD is found on?
What is its functin?

A

CD62L is found on T cells

It is an integrin for entry into the lymph node

23
Q

Interferon-γ (gamma)

What are the Main Cell Source?
Principal Targets?
Principal Effects?
What are the effects on...
MCH (which class?)
macrophages?
B cells?
Th cells?
A 
Main cells: NK cells, T cells 
Targets: macrophages, B cells, endothelium, DCs 
increased MHC class II expression, macrophage activation, IgG class switching, suppress Th2 cells
23
Q

CD20

What cell expresses?
What is its function?

A

NK have CD 20

Binds to Fc; releases granules TNF alpha and perforins; ADCC,

24
Q

CCR7

What is the source?
What is the target?
What is the mechanism?

A

Infected dendritic cells
T-cells
cytokines to attract T cells to infected dendricytes

immunology (1 decks)

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