CDs and Cytokines Flashcards
What are the Main Cells that Express
And what is the function of
CD3?
all T cells
associates with the TCR and mediates TCR signalling
What are the Main Cells that Express
And what is the function of
CD4?
T helper cells, MHC class II reactive T cells; monocytes, macrophages binds to MHC class II and helps in signalling for MHC II reactive T cells; binds to HIV
What are the Main Cells that Express
And what is the function of
CD8?
CTLs, MHC class I reactive T cells binds to MHC class I and helps in signalling for MHC I reactive T cells
What are the Main Cells that Express
And what is the function of
CD28?
T cells
Costimulatory molecule for T cell activation. Binds to CD80 and CD86
What are the Main Cells that Express
And what is the function of
CD40?
B cells, macrophages, DCs
Binds to CD154; involved in activation of B cells, DCs, and macrophages
What are the Main Cells that Express
And what is the function of
CD80 aka b7 and b7-1?
B cells, macrophages, DCs
Binds to CD28 and CTLA-4. Costimulator for T cell activation.
What are the Main Cells that Express
And what is the function of
CD86 aka b7-2?
B cells, macrophages, DCs
Binds to CD28 and CTLA-4. Costimulator for T cell activation.
What are the Main Cells that Express
And what is the function of
CD95 aka Fas, APO-1?
Activated T and B cells, monocytes
Induces apoptosis upon interaction with CD178
What are the Main Cells that Express
And what is the function of
CD154 aka CD40 ligand and CD40L?
Activated CD4+ T cells
Binds to CD40. Activates B cells, DCs, and macrophages
What are the Main Cells that Express
And what is the function of
CD178 aka Fas-ligand?
Induced on T cells and NK cells
Binds to Fas and induces apoptosis on Fas+ cells; important for regulation of the immune response.
IL-1 What are the Main Cell Source? Other Cell Sources? Principal Targets? Principal Effects? What are the effects on... Lymphocytes? Macrophages? Endothelium? Acute phase proteins?
main source: macrophages, B cells,NK cells
Second source: endothelium, fibroblasts, astrocytes, etc…
Targets: T cells, B cells, macrophages, endothelium
lymphocyte activation, macrophage stimulation, incr. leukocyte - endothelium adhesion; acute phase proteins, fever
IL-2 What are the Main Cell Source? Principal Targets? Principal Effects? What is the effect on... T cells? NK cells?
Main source: T cells
Cell Targets: T cells, NK cells
T cell and NK cell activation and proliferation
IL-4 What are the Main Cell Source? Principal Targets? Principal Effects? What is the effect on... B cells? Th2 cells? Th1 cells?
T cells, Th2 cells, mast cells
B cells, T cells
B cell growth factor, isotype switching to IgE, Th2 cell differentiation; suppress Th1 cells
IL-5 What are the Main Cell Source? Principal Targets? Principal Effects? What are the effects on... B cells? Eosinophils?
T cells, mast cells, Th2 cells
B cells
B cell growth factor, isotype switching to IgA; eosinophil growth
IL-6 What are the Main Cell Source? Other Cell Sources? Principal Targets? Principal Effects? What are the effects on... Acute phase response? Th17? B cells?
Main source: T, B, macrophages
Other sources: endothelium, fibroblasts, astrocytes, stromal cells etc…
Main targets: T, B, macrophages
Induces acute phase response; regulates Th17 differentiation, and proliferation of antibody producing cells
IL-10
What are the Main Cell Source? Principal Targets? Principal Effects? What are the effects on... Th1 cells? Macrophage cells?
T cells, Th2 cells
Th1 cells
inhibition of cytokine synthesis and macrophage function
IL-12
What are the Main Cell Source? Principal Targets? Principal Effects? What are the effects on... Th1 cells? NK cells?
monocytes, APCs
Th1 cells, NK cells
differentiation of Th1 cells; activation of NK cells
TNF-alpha
What are the Main Cell Source? Principal Targets? Principal Effects? What are the effects on... inflammation? endothelial cells? acute phase proteins? NK cells?
Main source: lymphocytes, macrophages, mast cells
Target cells: many cells
proinflammatory; endothelial activation, shock, acute phase proteins, PMN activation
TNF-beta
What are the Main Cell Source? Other Cell Sources? Principal Targets? Principal Effects? What are the effects on... inflammation? B cells
main source: T cells, monocytes
Other sources: most cells
Targets: most cells
inhibits cell activation, anti-inflammatory, promotes IgA secretion
Interferon-alpha/Beta
What are the Main Cell Source?
Other Cell Sources?
Principal Targets?
Principal Effects?
most cells
most cells
most cells
antiviral; increased MHC class I expression
CD 62L
What is the cell this CD is found on?
What is its functin?
CD62L is found on T cells
It is an integrin for entry into the lymph node
Interferon-γ (gamma)
What are the Main Cell Source? Principal Targets? Principal Effects? What are the effects on... MCH (which class?) macrophages? B cells? Th cells?
Main cells: NK cells, T cells Targets: macrophages, B cells, endothelium, DCs increased MHC class II expression, macrophage activation, IgG class switching, suppress Th2 cells
CD20
What cell expresses?
What is its function?
NK have CD 20
Binds to Fc; releases granules TNF alpha and perforins; ADCC,
CCR7
What is the source?
What is the target?
What is the mechanism?
Infected dendritic cells
T-cells
cytokines to attract T cells to infected dendricytes
